DVL3 and XPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DVL3	XPA
Description		dishevelled segment polarity protein 3	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Chromatin Cytoplasm Cytosol	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body
	Molecular Function	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Small GTPase-mediated Signal Transduction Response To Xenobiotic Stimulus Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Neuron Projection Arborization	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		172 interacting genes: ABT1 ADAM15 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BCL6 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 DYRK1A EIF1B EIF3D ENKD1 EVI2A FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PDE6C PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RAB18 RBM15B RBM39 RNF151 RPL11 RPS10 RPS5 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25	52 interacting genes: AP2M1 ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		1857	7507
HPRD ID		03222	02045
Ensembl ID		ENSG00000161202	ENSG00000136936
Uniprot IDs		Q92997	P23025
PDB IDs		6V7O 6ZBQ 6ZBZ 6ZC3 6ZC4 6ZC6 6ZC7 6ZC8 8S6A	1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Wnt Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Cellular Response To Endothelin Response To Endothelin Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Epigenetic Regulation Of Gene Expression Wnt Signalosome Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Chromatin Organization Nucleic Acid Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sequence-specific Double-stranded DNA Binding Heterochromatin Formation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Chromatin Remodeling U2-type Precatalytic Spliceosome Chromatin Silencing Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition
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