DUT and ESRRA

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
HPRD (two hybrid)

		DUT	ESRRA
Description		deoxyuridine triphosphatase	estrogen related receptor alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Extracellular Exosome	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Magnesium Ion Binding RNA Binding DUTP Diphosphatase Activity Protein Binding Hydrolase Activity Signaling Receptor Inhibitor Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development Nucleobase-containing Compound Metabolic Process DUMP Biosynthetic Process DTMP Biosynthetic Process DNA Replication Nucleotide Metabolic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Regulation Of Protein-containing Complex Assembly DUTP Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs		Deoxyuridine-5'-Diphosphate 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 31562340) Protein quantitative trait loci ( 18464913) Skin pigmentation ( 28300201)	Crohn's disease ( 21102463 28067908) Vitiligo ( 27723757)
Interacting Genes		10 interacting genes: BCAS2 CDK1 ESR1 ESRRA ESRRG NUDT18 PLEKHF2 PPARA PPARD SPATA2	37 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FAM9A FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA2 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARG PPARGC1A PRKCD PROX1 PSMC5 REL RNF4 RXRA SIRT1 SMARCD3 SP1 TNNI2
Entrez ID		1854	2101
HPRD ID		03165	07210
Ensembl ID		ENSG00000128951	ENSG00000173153
Uniprot IDs		A0A0C4DGL3 H0YNW5 P33316	P11474 Q569H8
PDB IDs		1Q5H 1Q5U 2HQU 3ARA 3ARN 3EHW 4MZ5 4MZ6 5H4J 7PWJ 8C8I	1XB7 2PJL 3D24 3K6P 7E2E
Enriched GO Terms of Interacting Partners?		Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Estrogen Response Element Binding Intracellular Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Steroid Binding Sequence-specific DNA Binding Transcription Coactivator Binding Regulation Of MiRNA Transcription Negative Regulation Of Cholesterol Storage Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Inflammatory Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Lipid Storage Regulation Of Fatty Acid Oxidation Intracellular Signal Transduction Response To Wounding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of Fatty Acid Metabolic Process Sequence-specific Double-stranded DNA Binding Fibroblast Proliferation Zinc Ion Binding Regulation Of Lipid Storage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Apoptotic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Pronuclear Fusion Positive Regulation Of Transformation Of Host Cell By Virus Linoleic Acid Binding 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process Regulation Of Heart Growth Regulation Of Developmental Growth Regulation Of Programmed Cell Death Lipid Binding Wound Healing Response To Activity Regulation Of Defense Response	Nuclear Receptor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Metabolic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Adipose Tissue Development Negative Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Transcription Coregulator Binding Nuclear Retinoic Acid Receptor Binding DNA Binding Domain Binding Regulation Of Adipose Tissue Development Retinoic Acid Receptor Signaling Pathway Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity LBD Domain Binding Circadian Regulation Of Gene Expression
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