CHRNE

Description		cholinergic receptor nicotinic epsilon subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Monoatomic Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs
Diseases		Congenital myasthenic syndrome
GWAS		Alzheimer's disease ( 34099642) Keratoconus ( 33649486) Platelet count ( 29403010)
Novel Interacting Genes		2 novel interacting genes: CHRNA1 DUSP6
Interacting Genes		2 interacting genes: CHRNA1 DUSP6
Entrez ID		1145
HPRD ID		00008
Ensembl ID		ENSG00000108556
Uniprot IDs		Q04844
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Binding Acetylcholine Receptor Activity Skeletal Muscle Tissue Growth Musculoskeletal Movement Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine-gated Channel Complex Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Synaptic Transmission, Cholinergic Muscle Cell Cellular Homeostasis Neuromuscular Junction Development Extracellular Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Skeletal Muscle Contraction Neuronal Action Potential Neuromuscular Synaptic Transmission Postsynaptic Specialization Membrane Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Response To Nicotine Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Membrane Depolarization ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade Neuromuscular Junction Striated Muscle Contraction Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Regulation Of Organ Growth Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Membrane Potential Action Potential Neuromuscular Process
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