RCAN1 and IL10RB

		RCAN1	IL10RB
Description		regulator of calcineurin 1	interleukin 10 receptor subunit beta
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Membrane Interleukin-28 Receptor Complex
	Molecular Function	Nucleic Acid Binding Protein Phosphatase Inhibitor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Identical Protein Binding	Interleukin-10 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Response To Ischemia Response To Stress Response To Oxidative Stress Skeletal Muscle Tissue Development Short-term Memory Response To Mechanical Stimulus Calcium-mediated Signaling Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Estrogen Skeletal Muscle Fiber Development Negative Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Cellular Respiration
Pathways			Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling
Drugs		Dipyridamole
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Blood protein levels ( 30072576) COVID-19 ( 33949668) Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Narcolepsy ( 23459209 24204295)
Interacting Genes		29 interacting genes: APP ATP5PO BTRC CBR3 CXXC5 DSCAM E2F3 GSK3B IL10RB ITSN1 KCNE1 MAP3K3 MAPK3 NEUROD2 PICK1 PPP3CA PPP3CB PPP3R1 PRDM4 PTPRD SF3A2 SON SOX10 SOX9 SPARCL1 USP22 UXT ZNF292 ZNF350	9 interacting genes: CBR3 IFNL2 IFNL3 IL10 IL10RA IL22 RCAN1 UCN2 UCN3
Entrez ID		1827	3588
HPRD ID		04226	00473
Ensembl ID		ENSG00000159200	ENSG00000243646
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	A0A1B0GTI5 A0A1B0GU52 Q08334
PDB IDs		6UUQ	3LQM 5T5W 6X93 9BPU 9BPV
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium-mediated Signaling Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Regulation Of Transcription By RNA Polymerase II Glial Cell Development Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcineurin-NFAT Signaling Cascade Protein Serine/threonine Phosphatase Complex Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Glutamatergic Synapse Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-NFAT Signaling Cascade Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Intracellular Signaling Cassette Cell Development Regulation Of Endocytosis Positive Regulation Of Calcium Ion Import Protein Dimerization Activity Calcineurin-mediated Signaling Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Monoatomic Ion Transport Regulation Of Vesicle-mediated Transport Calmodulin-dependent Protein Phosphatase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	Corticotropin-releasing Hormone Receptor Binding Extracellular Space Corticotropin-releasing Hormone Receptor 2 Binding Cytokine Activity Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Glucocorticoid Signaling Receptor Binding Response To Corticosteroid Signal Transduction Negative Regulation Of Inflammatory Response Digestion Response To Steroid Hormone Response To Hormone Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Extracellular Region Positive Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Defense Response Interleukin-10 Receptor Binding Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Lipid Negative Regulation Of Cytokine Activity Interleukin-10 Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Cell Surface Receptor Signaling Pathway Via STAT Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Interleukin-18 Production Regulation Of Cytokine Activity Interleukin-10 Receptor Activity Interleukin-22 Receptor Binding Regulation Of Inflammatory Response Negative Regulation Of Autophagy Response To Carbon Monoxide Hormone Activity NADPH Dehydrogenase (quinone) Activity Response To Stress Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Receptor Binding Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Positive Regulation Of Plasma Cell Differentiation 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Negative Regulation Of MHC Class II Biosynthetic Process Hormone-mediated Signaling Pathway
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