DSCAM and METAP2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCAM	METAP2
Description		DS cell adhesion molecule	methionyl aminopeptidase 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding	RNA Binding Aminopeptidase Activity Initiator Methionyl Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance	Regulation Of Translational Initiation Proteolysis Protein Processing
Pathways		DSCAM interactions DSCAM interactions	Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Methionine Nitroxoline 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium Fumagillin D-Methionine N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide (2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-N-[(3S,6R)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-8,8-dimethyl-6-nonenamide tert-butanol (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide Ovalicin PPI-2458 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID TNP-470
Diseases
GWAS		Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Blood protein levels ( 30072576) C-reactive protein levels ( 30388399) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels ( 23823483) Reticulocyte count ( 32888494)
Interacting Genes		161 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNJ15 KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PCP4 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCAN1 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC3 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365	16 interacting genes: APP CALM1 CDC42 CEBPA DSCAM EIF2AK2 EIF2S3 FBXL17 HMGA1 MAPK1 MAPK3 OGT PJA1 RAC1 S100A4 YWHAE
Entrez ID		1826	10988
HPRD ID		03953	03522
Ensembl ID		ENSG00000171587	ENSG00000111142
Uniprot IDs		O60469	A0A140VJE3 F8VQZ7 P50579
PDB IDs		6ZR7	1B59 1B6A 1BN5 1BOA 1KQ0 1KQ9 1QZY 1R58 1R5G 1R5H 1YW7 1YW8 1YW9 2ADU 2EA2 2EA4 2GA2 2OAZ 5CLS 5D6E 5D6F 5JFR 5JHU 5JI6 5LYW 5LYX 6QED 6QEF 6QEG 6QEH 6QEI 6QEJ 7A12 7A13 7A14 7A15 7A16 8ONY 8OXG 9FPZ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding	Intracellular Signal Transduction Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Response To Peptide Response To Cytokine Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Focal Adhesion Endocytosis Regulation Of Intracellular Signal Transduction Interleukin-34-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Regulation Of Golgi Inheritance Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Calcium Ion Export Across Plasma Membrane Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Signal Transduction Positive Regulation Of Leukocyte Migration Substantia Nigra Development Positive Regulation Of Locomotion Regulation Of Calcium Ion Export Across Plasma Membrane Import Into Cell Regulation Of Granulocyte Chemotaxis Positive Regulation Of Inflammatory Response G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Glial Cell Development Neural Nucleus Development Cellular Response To Amino Acid Starvation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Amino Acid Starvation Cellular Response To Cytokine Stimulus Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Signal Transduction Thioesterase Binding Bergmann Glial Cell Differentiation Vesicle-mediated Transport
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