DPAGT1 and TUBE1

		DPAGT1	TUBE1
Description		dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	tubulin epsilon 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle	Pericentriolar Material Cytoplasm Centrosome Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Identical Protein Binding Metal Ion Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Centrosome Cycle
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes CDG-1j, CMSTA2
Drugs			Vinblastine
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		2 interacting genes: LSM8 SLC33A2
Entrez ID		1798	51175
HPRD ID		01879	06298
Ensembl ID		ENSG00000172269	ENSG00000074935
Uniprot IDs		A0A804HI18 A0A804HKZ3 Q9H3H5	Q9UJT0
PDB IDs		5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3
Enriched GO Terms of Interacting Partners?			UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Anion Channel Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity
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