DMPK and CELF1

Number of citations of the paper that reports this interaction (PubMedID 9371827)
21

Data Source:
HPRD (in vitro)

		DMPK	CELF1
Description		DM1 protein kinase	CUGBP Elav-like family member 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Nuclear Membrane Mitochondrial Membrane Sarcoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Perinucleolar Compartment Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Pre-mRNA Binding BRE Binding
	Biological Process	Regulation Of Sodium Ion Transport Protein Phosphorylation Intracellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Regulation Of Synapse Structural Plasticity	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing Germ Cell Development Negative Regulation Of Cell Population Proliferation RNA Splicing Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Post-transcriptional Gene Silencing Negative Regulation Of Translation Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Splicing Regulation Of Inflammatory Response MRNA Destabilization
Pathways		Ion homeostasis
Drugs		Bisindolylmaleimide VIII
Diseases		Myotonic dystrophy (DM)
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Immature fraction of reticulocytes ( 32888494 27863252) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Metabolic syndrome ( 31589552) Neuroticism ( 29255261) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		20 interacting genes: ANXA7 ATN1 ATXN1 CDC73 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A PVR RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	49 interacting genes: APP CEBPA DMPK FUBP1 MIR106B MIR107 MIR10B MIR128-1 MIR138-2 MIR140 MIR143 MIR155 MIR15B MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I OGT PPBP RALY RNF10 TOM1L1
Entrez ID		1760	10658
HPRD ID		05645	03046
Ensembl ID		ENSG00000104936	ENSG00000149187
Uniprot IDs		B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013	G5EA30 Q92879
PDB IDs		1WT6 2VD5	2CPZ 2DHS 2RQ4 2RQC 3NMR 3NNA 3NNC 3NNH
Enriched GO Terms of Interacting Partners?		Regulation Of Cardiac Muscle Cell Membrane Potential G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Protein-containing Complex Organization SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Motor Neuron Axon Guidance Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Developmental Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Rhombomere 3 Morphogenesis Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Cis-trans Isomerase Activity Cellular Component Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Protein Glutathionylation Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Insulin-like Growth Factor Receptor Signaling Pathway Spliceosomal SnRNP Assembly Response To Lipid Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Rhombomere 2 Development Positive Regulation Of Transcription By RNA Polymerase II Cytosol Enzyme Inhibitor Activity Focal Adhesion Regulation Of Biological Quality Positive Regulation Of Protein Phosphorylation Visual Behavior Regulation Of The Force Of Heart Contraction By Cardiac Conduction Visual Learning Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation MRNA Destabilization RNA Destabilization Extracellular Space Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Positive Regulation Of MRNA Catabolic Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cytokine Production Regulation Of Locomotion Regulation Of Developmental Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process
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