DLG1 and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 12933808)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vivo, in vitro)

		DLG1	CAMK2A
Description		discs large MAGUK scaffold protein 1	calcium/calmodulin dependent protein kinase II alpha
Image
GO Annotations	Cellular Component	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse
	Molecular Function	GMP Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Kinase Binding Protein Kinase Binding Phosphatase Binding Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Nervous System Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Actin Filament Polymerization Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Membrane Raft Organization Regulation Of Myelination Regulation Of Protein Localization Protein Localization To Synapse T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Tissue Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Membrane Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways		Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Allergic rhinitis ( 25085501) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) PR interval ( 32439900) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)
Interacting Genes		81 interacting genes: ACTA1 ACTN2 ACVR2B ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 APC ARHGEF26 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 DSCAM EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TIAM1 TJAP1 UBASH3A UBE3A WAS WNT3A	90 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NDST1 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		1739	815
HPRD ID		03007	06532
Ensembl ID		ENSG00000075711	ENSG00000070808
Uniprot IDs		A0A0C4DFT3 A0A590UJ08 A0A590UJ68 A0A590UJD9 A0A590UJX2 A0A590UK48 A0A590UKA8 B4DF78 Q12959	A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69 7PC3 8CN1 8CN3	2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Plasma Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Metal Ion Transport PDZ Domain Binding Regulation Of Membrane Potential Monoatomic Ion Channel Complex Postsynaptic Density Membrane Monoatomic Cation Transport Monoatomic Ion Transport Regulation Of Monoatomic Ion Transport Dendritic Spine Dendrite Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Voltage-gated Potassium Channel Complex System Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Inorganic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Regulation Of System Process Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Transmembrane Transport Cell Projection Monoatomic Ion Channel Activity Neuron Projection Postsynaptic Membrane Nervous System Process Positive Regulation Of Synaptic Transmission Action Potential Regulation Of Multicellular Organismal Process Potassium Ion Transmembrane Transport Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Potassium Ion Transport Membrane Trans-synaptic Signaling Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Cell-cell Junction Modulation Of Excitatory Postsynaptic Potential Signal Transduction Axon Signaling	Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?