DIO3 and PRMT7

Number of citations of the paper that reports this interaction (PubMedID 17709427)
33

Data Source:
BioGRID (pull down)

		DIO3	PRMT7
Description		iodothyronine deiodinase 3	protein arginine methyltransferase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Thyroxine 5'-deiodinase Activity Oxidoreductase Activity Thyroxine 5-deiodinase Activity	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Histone H4 Methyltransferase Activity
	Biological Process	Response To Hypoxia Apoptotic Process Positive Regulation Of Multicellular Organism Growth Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Retinal Cone Cell Development Brown Fat Cell Proliferation Retinal Cone Cell Apoptotic Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Peptidyl-arginine Methylation Cell Differentiation Methylation Genomic Imprinting
Pathways		Regulation of thyroid hormone activity	RMTs methylate histone arginines
Drugs		Iopodic acid
Diseases
GWAS		Metabolite levels ( 23823483) Pulse pressure ( 30224653) Type 1 diabetes ( 19966805)	A body shape index ( 34021172) Birth weight ( 31043758) Body mass index ( 25673413 28892062) Lipoprotein (a) levels ( 33730874) Magnesium levels ( 20700443) Offspring birth weight ( 31043758) Refractive error ( 32231278) Schizophrenia ( 31579629) Serum metabolite levels ( 23093944) Weight ( 28552196)
Interacting Genes		5 interacting genes: APP C1QBP CKB PRMT5 PRMT7	15 interacting genes: CTCFL DIO3 EIF2S1 H2AC20 H3-5 H3C1 H4C1 MNDA NFKBID POT1 SNRPB TRIO UBC ZBTB24 ZNF438
Entrez ID		1735	54496
HPRD ID		11867	15174
Ensembl ID		ENSG00000197406	ENSG00000132600
Uniprot IDs		P55073 Q86TU3	A0A8I5KPP4 A0A8I5KXS9 A0A8I5KYD6 A0A8I5KZ05 A0A8I5KZ92 H3BNC0 Q9NVM4
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine N-methyltransferase Activity Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Protein Methylation Ribonucleoprotein Complex Binding Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Adrenergic Receptor Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Type II Interferon Production Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kininogen Binding Deoxyribonuclease Inhibitor Activity Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Futile Creatine Cycle Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Macromolecule Methylation Methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus	Structural Constituent Of Chromatin Nucleosome DNA Binding Chromosome Nucleus Protein Heterodimerization Activity Telomere Organization Translation Initiation Ternary Complex Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Retinal Cone Cell Apoptotic Process Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Brown Fat Cell Proliferation Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Nucleoplasm SnRNP Binding U2 SnRNP Binding Chromatin Remodeling Epigenetic Regulation Of Gene Expression Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding
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