DIO1 and ARTN

		DIO1	ARTN
Description		iodothyronine deiodinase 1	artemin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Thyroxine 5-deiodinase Activity	Signaling Receptor Binding Protein Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding
	Biological Process	Amino Acid Metabolic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process	Signal Transduction Nervous System Development Neuroblast Proliferation Axon Guidance Peripheral Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Peyer's Patch Morphogenesis Lymphocyte Migration Into Lymphoid Organs
Pathways		Regulation of thyroid hormone activity	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Free thyroxine concentration ( 25743335) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thyroid hormone levels ( 23408906)	Autism spectrum disorder or schizophrenia ( 28540026) Tea consumption ( 31046077)
Interacting Genes			1 interacting genes: GFRA3
Entrez ID		1733	9048
HPRD ID		01002	04863
Ensembl ID		ENSG00000211452	ENSG00000117407
Uniprot IDs		A8K415 P49895	Q5T4W7
PDB IDs			2ASK 2GH0 2GYR 2GYZ 6Q2S
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Binding Peyer's Patch Morphogenesis Lymphocyte Migration Into Lymphoid Organs Induction Of Positive Chemotaxis Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Positive Chemotaxis Peripheral Nervous System Development Natural Killer Cell Activation Neuroblast Proliferation Lymphocyte Migration Receptor Tyrosine Kinase Binding
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