DHPS and UPF1

		DHPS	UPF1
Description		deoxyhypusine synthase	UPF1 RNA helicase and ATPase
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Transferase Activity Deoxyhypusine Synthase Activity Identical Protein Binding	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity Telomeric DNA Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Proliferation Glucose Homeostasis Spermidine Catabolic Process Protein Maturation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Regulation Of Gene Expression Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Pathways		Hypusine synthesis from eIF5A-lysine	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		1-Guanidinium-7-Aminoheptane
Diseases
GWAS		Platelet distribution width ( 32888494)	Attention deficit hyperactivity disorder ( 32595297)
Interacting Genes		17 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 UPF1 VASH1 ZNF138	112 interacting genes: ABHD16A ACRV1 ACSS2 AP1G1 ATR CEBPA CNN1 CSNK2B DCP1A DCP2 DHPS DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LDB1 LINC00113 LSM8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NADSYN1 NDRG1 NDUFB10 NOTCH3 PLEKHA5 PLEKHB2 POLR2A PTEN RHOXF2 RNF10 RPRD2 SMG1 SMG5 STAU1 SUMO2 UPF2 UPF3A UPF3B XRN1
Entrez ID		1725	5976
HPRD ID		02969	03254
Ensembl ID		ENSG00000095059	ENSG00000005007
Uniprot IDs		P49366	A0A024R7L5 B3KY55 Q92900
PDB IDs		1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM 7A6S 7A6T 8A0E 8A0F 8A0G 8PVU 8R3U	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5 6Z3R 8RXB
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Termination Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Elongation Translation Elongation Factor Activity Regulation Of Protein-containing Complex Disassembly Cytoplasm Positive Regulation Of Protein-containing Complex Disassembly Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein-N-terminal Glutamine Amidohydrolase Activity 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Destabilization MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus
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