SPTSSA and BBS2

		SPTSSA	BBS2
Description		serine palmitoyltransferase small subunit A	Bardet-Biedl syndrome 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Intracellular Protein Localization Sphingolipid Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Sphingolipid de novo biosynthesis	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Intraocular pressure ( 29785010 31959993)
Interacting Genes		10 interacting genes: AKAP6 BBS2 CYSRT1 GET1 GLP1R HERPUD2 RHBDL1 TMEM31 TUBB3 VKORC1	27 interacting genes: APOC2 BHMT CES1 CETP CNOT1 EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B GOT2 HNRNPF HSCB HSF4 KCNK17 KRT18 LMO4 MAP2K5 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS SPTSSA UBC WRNIP1
Entrez ID		171546	583
HPRD ID		16610	05855
Ensembl ID		ENSG00000165389	ENSG00000125124
Uniprot IDs		Q969W0	A0A804HIE1 A0A804HKG1 Q9BXC9
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0I 7K0J 7K0K 7K0L 7K0M 7K0N 7K0O 7K0P 7K0Q 7YIU 7YIY 7YJ1 7YJ2
Enriched GO Terms of Interacting Partners?			Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center
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