LCA5 and RCOR3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LCA5	RCOR3
Description		lebercilin LCA5	REST corepressor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitochondrion Centrosome Cytoskeleton Cilium Axoneme Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	Protein Binding Protein-containing Complex Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Transport Intraciliary Transport Photoreceptor Cell Maintenance	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR)
GWAS		Glucose homeostasis traits ( 25524916) Hoarding ( 21302353) Presence of antiphospholipid antibodies ( 23509613)	Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: GCC1 RCOR3 SRPK2 SUFU TFIP11 TXLNA	75 interacting genes: ABI1 ANKRD11 APP BORCS6 CBY2 CCDC102B CCDC106 CCHCR1 CDR2 CEP55 CEP63 CEP70 EFHC2 FAM81A FSD2 GKAP1 GLRX3 GOLGA2 GPRASP3 GRIPAP1 GSE1 HAUS3 HMBOX1 HOOK2 HSF2BP ICA1L IKZF3 ING5 ISY1-RAB43 KDM1A KRT15 KRT18 KRT19 KRT24 KRT27 KRT31 KRT40 KRT75 LCA5 LHX3 LUZP4 LZTS2 MAGEA6 MARK3 MCC MESD MID2 MIPOL1 MTUS2 NDUFB7 NECAB2 NINL NRDE2 NUTM1 PHF19 PIH1D1 PRDM14 PTPN11 PTTG2 STN1 SUMO2 TFIP11 TRAF1 TRAF2 TRIM27 TRIM42 TRIM54 TSGA10 TULP3 TXLNA USHBP1 VAX1 YWHAQ ZNF383 ZNF688
Entrez ID		167691	55758
HPRD ID		10791	08338
Ensembl ID		ENSG00000135338	ENSG00000117625
Uniprot IDs		A0A384MDJ7 Q86VQ0	Q9P2K3
PDB IDs			4CZZ
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Nuclear Speck Organization GLI-SUFU Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere Transcription Corepressor Activity Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning Golgi Trans Cisterna R-loop Processing	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Protein Binding Identical Protein Binding Supramolecular Fiber Organization Microtubule TORC1 Complex Assembly Cytoskeleton Organization Epithelial Cell Differentiation Microtubule-based Process Telomeric DNA Binding Centrosome
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