DEFB4A and KCNA3

Number of citations of the paper that reports this interaction (PubMedID 25944908)
25

Data Source:
BioGRID (pull down)

		DEFB4A	KCNA3
Description		defensin beta 4A	potassium voltage-gated channel subfamily A member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Chemotaxis Cell Chemotaxis Antifungal Innate Immune Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Beta defensins Defensins	Voltage gated Potassium channels
Drugs			Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464)
Interacting Genes		3 interacting genes: CCR6 KCNA3 TLR4	11 interacting genes: BAX CAV1 CD3D CSNK2B DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2
Entrez ID		1673	3738
HPRD ID		03739	15937
Ensembl ID		ENSG00000171711	ENSG00000177272
Uniprot IDs		O15263	P22001
PDB IDs		1E4Q 1FD3 1FD4 1FQQ 6CS9 8YD6	4BGC 7EJ1 7EJ2 7SSV 7SSX 7SSY 7SSZ 8DFL
Enriched GO Terms of Interacting Partners?		B Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Cell Activation Involved In Immune Response B Cell Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Nitric Oxide Production Involved In Inflammatory Response Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Thymocyte Migration Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Signaling Receptor Activity DN2 Thymocyte Differentiation Lipopolysaccharide Receptor Complex Mononuclear Cell Differentiation T Cell Activation Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Lipopolysaccharide B Cell Proliferation Involved In Immune Response External Side Of Plasma Membrane Lipopolysaccharide Immune Receptor Activity Leukocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Immune Effector Process Sperm Plasma Membrane Positive Regulation Of Flagellated Sperm Motility Voltage-gated Monoatomic Ion Channel Activity Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-23 Production Cellular Response To Lipoteichoic Acid Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Intestinal Epithelial Structure Maintenance TRIF-dependent Toll-like Receptor Signaling Pathway NK T Cell Activation Microglia Differentiation T-helper 1 Type Immune Response Regulation Of Dendritic Cell Chemotaxis Lymphocyte Activation Positive Regulation Of Cilium Movement Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Molecule Of Bacterial Origin Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Platelet Activation	Juxtaparanode Region Of Axon Regulation Of Membrane Potential Endoplasmic Reticulum Voltage-gated Potassium Channel Complex Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Epithelial Cell Proliferation Cellular Response To Topologically Incorrect Protein Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Metal Ion Transport Signal Transduction Regulation Of Transport Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Monoatomic Ion Transport Membrane Raft Organization Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Cell Action Potential Protein Localization To Postsynaptic Membrane Membrane Repolarization During Action Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Membrane Repolarization Neuronal Action Potential Axon Initial Segment Delayed Rectifier Potassium Channel Activity Localization Within Membrane Endothelial Cell Proliferation Cell Junction Positive Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Regulation Of System Process Protein-macromolecule Adaptor Activity Regulation Of Calcium Ion Transport Protein Localization To Cell Periphery Metal Ion Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Muscle System Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Immune System Process T Cell Homeostatic Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport BAX Complex Cell Surface Receptor Signaling Pathway Release Of Matrix Enzymes From Mitochondria
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