DECR1 and CLCN3

		DECR1	CLCN3
Description		2,4-dienoyl-CoA reductase 1	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	2,4-dienoyl-CoA Reductase (NADPH) Activity Oxidoreductase Activity Identical Protein Binding NADPH Binding	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Positive Regulation Of Cold-induced Thermogenesis	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	Stimuli-sensing channels
Drugs		Nicotinamide adenine dinucleotide phosphate 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
Diseases
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		4 interacting genes: APP CLCN3 HGS MMP16	17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 NHERF1 PDGFB PDZK1 VPS18
Entrez ID		1666	1182
HPRD ID		01959	02785
Ensembl ID		ENSG00000104325	ENSG00000109572
Uniprot IDs		Q16698	B3KXK0 E9PE15 P51790
PDB IDs		1W6U 1W73 1W8D
Enriched GO Terms of Interacting Partners?		Early Endosome Membrane Early Endosome Membrane Invagination Lysosome Positive Regulation Of Reactive Oxygen Species Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Adult Locomotory Behavior Cell Surface Regulation Of Response To Calcium Ion Golgi Lumen Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Endosome Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chloride:proton Antiporter Activity ESCRT-0 Complex Locomotory Behavior Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Phagocytic Vesicle Lumen Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity	Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity
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