DDB2 and DCLRE1C

Number of citations of the paper that reports this interaction (PubMedID 22134138)
68

Data Source:
BioGRID (pull down)

		DDB2	DCLRE1C
Description		damage specific DNA binding protein 2	DNA cross-link repair 1C
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cell Junction Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Nucleus Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair DNA Damage Response Response To UV Protein Ubiquitination Cellular Response To UV Protein Autoubiquitination UV-damage Excision Repair	Telomere Maintenance Adaptive Immune Response Immune System Process DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Interstrand Cross-link Repair Chromosome Organization
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Lymphocyte count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1
Entrez ID		1643	64421
HPRD ID		02886	05817
Ensembl ID		ENSG00000134574	ENSG00000152457
Uniprot IDs		Q92466	A0A8V8TKN9 A0A8V8TLX1 B3KMX5 Q96SD1
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7ABS 7AF1 7AFS 7AFU 7AGI 7APV 7SGL 7TYR
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding UV-damage Excision Repair Response To Radiation Nucleoplasm DNA Metabolic Process DNA Repair DNA Damage Response Nucleus Response To UV DNA Binding Cellular Response To Radiation Cellular Response To UV Macromolecule Metabolic Process Cellular Response To Light Stimulus Nucleic Acid Metabolic Process Chromatin Remodeling Rhythmic Process Cul4A-RING E3 Ubiquitin Ligase Complex Chromatin Binding Response To Light Stimulus Chromatin Organization Cellular Response To Stress Regulation Of Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Protein Modification Process Cul4-RING E3 Ubiquitin Ligase Complex Nuclear Chromosome Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Sensor Activity Chromatin Positive Regulation Of Morphogenesis Of An Epithelium Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Morphogenesis Of A Branching Structure Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Regulation Of Macromolecule Metabolic Process Chromosome Organization Regulation Of Blood Vessel Branching Bubble DNA Binding Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway Embryonic Cleavage	DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Regulation Of DNA Metabolic Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle Process DNA Repair Regulation Of Double-strand Break Repair Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition BRCA1-C Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Chromosome, Telomeric Region DNA Metabolic Process Regulation Of Cell Cycle Process Telomere Maintenance Homologous Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Telomere Organization Regulation Of Cellular Response To Stress Cellular Response To Stress Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Histone H2AXS139 Kinase Activity Chromatin Remodeling Mitotic DNA Damage Checkpoint Signaling Chromosome Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Telomere Maintenance Chromosomal Region Telomeric 3' Overhang Formation DNA Double-strand Break Processing Protein Localization To Site Of Double-strand Break Chromatin Organization Positive Regulation Of Double-strand Break Repair
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?