SPPL2C and RETREG3

		SPPL2C	RETREG3
Description		signal peptide peptidase like 2C	reticulophagy regulator family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Golgi-associated Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity Molecular Adaptor Activity	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity
	Biological Process	Acrosome Assembly Proteolysis Membrane Protein Ectodomain Proteolysis Intracellular Calcium Ion Homeostasis Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Sperm-egg Recognition Protein Stabilization	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561 33909500) Hand grip strength ( 29691431) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic pulmonary fibrosis ( 24429156) Male-pattern baldness ( 28196072) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Red blood cell count ( 27863252) Waist-hip index ( 34021172)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		4 interacting genes: CYSRT1 NBPF19 NOTCH2NLA RETREG3	111 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARHGAP27 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 KANSL1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUNDC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 SPPL2C STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6
Entrez ID		162540	162427
HPRD ID		07085	14108
Ensembl ID		ENSG00000185294	ENSG00000141699
Uniprot IDs		Q8IUH8	K7EQI9 Q86VR2
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway
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