CLEC14A and CLDN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC14A	CLDN4
Description		C-type lectin domain containing 14A	claudin 4
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane Extracellular Matrix	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Lymphangiogenesis Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway	Monoatomic Ion Transport Chloride Transport Cell Adhesion Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Monoatomic Ion Transmembrane Transport Establishment Of Skin Barrier Renal Absorption Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Paracellular Transport Chloride Transmembrane Transport
Pathways			Tight junction interactions
Drugs		Resveratrol
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Two-hour glucose ( 34059833) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3	19 interacting genes: AQP6 ARL13B CLEC14A EPHA2 FAM209A FFAR2 GJA8 GOLM1 HSD17B13 ICAM3 SHBG SLC71A2 SYT2 TJP1 TMEM237 TMEM52B TRIM59 TSPO2 WNK4
Entrez ID		161198	1364
HPRD ID		10711	04218
Ensembl ID		ENSG00000176435	ENSG00000189143
Uniprot IDs		Q86T13	O14493 Q75L80
PDB IDs			5B2G 7KP4 7TDM 7TDN 8U4V 8U5B 9CMH 9CMI
Enriched GO Terms of Interacting Partners?		Membrane Paracellular Transport Myelination Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Plasma Membrane Tight Junction Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly TMEM240-body	Membrane
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