CYP51A1 and STT3B

		CYP51A1	STT3B
Description		cytochrome P450 family 51 subfamily A member 1	STT3 oligosaccharyltransferase complex catalytic subunit B
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Protein-containing Complex Oligosaccharyltransferase Complex B
	Molecular Function	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Negative Regulation Of Amyloid-beta Clearance	Protein Glycosylation Protein N-linked Glycosylation Glycoprotein Catabolic Process Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine ERAD Pathway Post-translational Protein Modification
Pathways		Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination	Asparagine N-linked glycosylation Maturation of spike protein Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		Tioconazole Itraconazole Levoketoconazole (S)-econazole
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Diabetic retinopathy in type 2 diabetes ( 33607655) Periodontal disease-related phenotype (Socransky) ( 24347629) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: GRM3 SHANK3 STT3B TMUB1 ZNF420	12 interacting genes: AADAT CAMLG CYP51A1 DDR2 EIF4H FILNC1 GNMT INCA1 OXSR1 SATB1 SMARCC1 XYLB
Entrez ID		1595	201595
HPRD ID		03381	12268
Ensembl ID		ENSG00000001630	ENSG00000163527
Uniprot IDs		Q16850	Q8TCJ2
PDB IDs		3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ 8SBI 8SS0	6S7T
Enriched GO Terms of Interacting Partners?		Postsynaptic Membrane Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic ERAD Pathway Group II Metabotropic Glutamate Receptor Activity Guanylate Kinase-associated Protein Clustering Oligosaccharyl Transferase Activity Dendritic Spine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Postsynaptic Density Neuron Projection Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Response To Endoplasmic Reticulum Stress Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity GABAergic Neuron Differentiation Neurotransmitter-gated Ion Channel Clustering Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Oligosaccharyltransferase Complex B Oligosaccharyltransferase Complex Auditory Behavior Regulation Of Long-term Synaptic Depression G Protein-coupled Glutamate Receptor Signaling Pathway Mechanosensory Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Protein N-linked Glycosylation Via Asparagine Cellular Response To Stress Positive Regulation Of Long-term Synaptic Potentiation Proteasomal Protein Catabolic Process Postsynaptic Specialization Organization Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity	Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Xylulose Catabolic Process D-xylulokinase Activity Aspartate Family Amino Acid Metabolic Process Glycine N-methyltransferase Activity Methionine-glyoxylate Transaminase Activity Glycine:2-oxoglutarate Aminotransferase Activity 2-aminoadipate Transaminase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Hepatic Stellate Cell Proliferation Protein Tyrosine Kinase Collagen Receptor Activity RNA Strand-exchange Activity Eukaryotic Translation Initiation Factor 4F Complex Assembly Xylulose Metabolic Process Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Kynurenine-glyoxylate Transaminase Activity GET Complex Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Fibroblast Proliferation D-xylose Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
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