MAGEB6 and HACL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MAGEB6	HACL1
Description		MAGE family member B6	2-hydroxyacyl-CoA lyase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleoplasm Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Catalytic Activity Protein Binding ATP Binding Lyase Activity Carbon-carbon Lyase Activity Thiamine Pyrophosphate Binding Identical Protein Binding Metal Ion Binding 2-hydroxyacyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Fatty Acid Alpha-oxidation Protein Targeting To Peroxisome Lipid Metabolic Process Fatty Acid Metabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process
Pathways			Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS			C-reactive protein levels ( 29878111)
Interacting Genes		7 interacting genes: APBA2 ATXN1 HACL1 HTT PHC2 ROBO1 SUPV3L1	5 interacting genes: CFTR MAGEB6 MAPK6 PEX5 ZMYND19
Entrez ID		158809	26061
HPRD ID		06628	09183
Ensembl ID		ENSG00000176746	ENSG00000131373
Uniprot IDs		Q8N7X4	B4DXR1 Q9UJ83
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Mitochondrial RNA Surveillance Mitochondrial NcRNA Surveillance Mitochondrial MRNA Surveillance 2-hydroxyacyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Learning Positive Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration POZ Domain Binding Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process Locomotory Behavior Vocal Learning LRR Domain Binding Heart Induction Axon Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Poly(G) Binding Mitochondrial RNA 3'-end Processing Mitochondrial RNA Catabolic Process 3'-5' RNA Helicase Activity Fatty Acid Alpha-oxidation Thiamine Pyrophosphate Binding Observational Learning Positive Regulation Of Neurogenesis Regulation Of Heart Morphogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Carbon-carbon Lyase Activity Brain Development Profilin Binding Protein Targeting To Peroxisome Axon Guidance Receptor Activity Learning Or Memory Endocardial Cushion Formation Positive Regulation Of Nervous System Development Nuclear Inclusion Body	Positive Regulation Of Anion Channel Activity Protein-containing Complex Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Septin Cytoskeleton Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Positive Regulation Of Enamel Mineralization Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Positive Regulation Of Developmental Process Golgi-associated Vesicle Membrane Protein Unfolding Protein Import Into Peroxisome Matrix Cellular Response To Forskolin Response To Forskolin MAP Kinase Activity Pexophagy Enzyme Binding Chloride Transmembrane Transporter Activity Sperm Capacitation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Cerebral Cortex Neuron Differentiation Bicarbonate Transport
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