NKX6-3 and IDO2

		NKX6-3	IDO2
Description		NK6 homeobox 3	indoleamine 2,3-dioxygenase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Determination Glandular Epithelial Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Enteroendocrine Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation	Immune System Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine 'de Novo' NAD+ Biosynthetic Process From L-tryptophan
Pathways			Tryptophan catabolism
Drugs
Diseases
GWAS		Birth weight ( 31043758) Red cell distribution width ( 28957414) Type 2 diabetes ( 32499647)	Schizophrenia x sex interaction ( 34099189)
Interacting Genes		1 interacting genes: IDO2	7 interacting genes: BANP GINS4 GPAT4 HOOK3 LZTS1 NKX6-3 SMIM19
Entrez ID		157848	169355
HPRD ID		08053	14113
Ensembl ID		ENSG00000165066	ENSG00000188676
Uniprot IDs		A6NJ46	Q6ZQW0
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' NAD+ Biosynthetic Process From L-tryptophan Kynurenine Metabolic Process L-tryptophan Catabolic Process To Kynurenine Indoleamine 2,3-dioxygenase Activity L-tryptophan Catabolic Process Tryptophan 2,3-dioxygenase Activity L-tryptophan Metabolic Process NAD+ Biosynthetic Process Benzene-containing Compound Metabolic Process Aromatic Amino Acid Family Catabolic Process Pyridine Nucleotide Biosynthetic Process Aromatic Amino Acid Metabolic Process NAD+ Metabolic Process Dioxygenase Activity Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process Ketone Metabolic Process Amino Acid Catabolic Process Nicotinamide Nucleotide Metabolic Process Heme Binding L-amino Acid Metabolic Process Purine Nucleotide Biosynthetic Process Alpha-amino Acid Metabolic Process Nucleotide Biosynthetic Process Carboxylic Acid Catabolic Process Purine-containing Compound Biosynthetic Process Amino Acid Metabolic Process Nucleoside Phosphate Biosynthetic Process Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Oxidoreductase Activity Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
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