AGR3 and ASB10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AGR3	ASB10
Description		anterior gradient 3, protein disulphide isomerase family member	ankyrin repeat and SOCS box containing 10
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum	Nucleus Cytoplasm Cytosol
	Molecular Function	Dystroglycan Binding Protein Binding	Protein Binding
	Biological Process		Protein Ubiquitination Intracellular Signal Transduction
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coffee consumption ( 29367735 31959922) Cutaneous malignant melanoma ( 26237428 32341527) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Eyebrow thickness ( 26926045) Renal underexcretion gout ( 32238385)
Interacting Genes		36 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 BZW2 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2	7 interacting genes: AGR3 ANTXR1 ARFGAP1 KDM1A LCN2 MEOX2 MRPL23
Entrez ID		155465	136371
HPRD ID		16545	10666
Ensembl ID		ENSG00000173467	ENSG00000146926
Uniprot IDs		Q8TD06	A0A090N8I2 Q8WXI3
PDB IDs		3PH9
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of ERAD Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Glial Cell Differentiation ERAD Pathway Positive Regulation Of Protein Catabolic Process Membrane Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Fluid Shear Stress Regulation Of Protein Catabolic Process Proteolysis Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Decreased Oxygen Levels Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Catabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Protein Localization To Centrosome Cellular Response To Oxygen Levels Positive Regulation Of Gliogenesis Regulation Of Sodium Ion Transport Regulation Of Glial Cell Differentiation Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Tail-anchored Membrane Protein Insertion Into ER Membrane Lamellipodium Regulation Of Metal Ion Transport Laminin Binding Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Response To Laminar Fluid Shear Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Catabolic Process Autophagosome Assembly Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Enterobactin Binding Cellular Response To Ionizing Radiation Positive Regulation Of Endothelial Tube Morphogenesis Response To Toxic Substance Iron Ion Sequestering Activity Positive Regulation Of Cold-induced Thermogenesis Ribosomal Subunit Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Response To Herbicide Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Regulation Of Cold-induced Thermogenesis Cellular Response To Radiation Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Response To Ionizing Radiation Somite Specification MRF Binding Protein Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Iron Ion Transport Response To Blue Light Response To Fungicide Guanine Metabolic Process Regulation Of Endothelial Cell Migration Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Histone H3K4 Demethylase Activity Cellular Response To X-ray Response To Fructose Histone H3K9 Demethylase Activity Negative Regulation Of Extracellular Matrix Assembly Dystroglycan Binding
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