VKORC1L1 and TMEM80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VKORC1L1	TMEM80
Description		vitamin K epoxide reductase complex subunit 1L1	transmembrane protein 80
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cilium Membrane Ciliary Transition Zone Cell Projection
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Protein Binding
	Biological Process	Peptidyl-glutamic Acid Carboxylation Cellular Response To Oxidative Stress Vitamin K Metabolic Process	Non-motile Cilium Assembly
Pathways		Metabolism of vitamin K
Drugs		Menadione
Diseases
GWAS		Calcium levels ( 24068962) Corneal structure ( 23291589) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 30591961) Neutrophil count ( 32888494)
Interacting Genes		9 interacting genes: AQP6 CISD2 ERGIC3 GORAB GPX8 MRM1 MS4A3 MTIF3 TMEM80	65 interacting genes: ADGRE2 AGTR1 AIG1 AQP1 ARL6IP6 BET1 BIK C11orf24 C14orf180 C3orf52 C5orf46 CCDC167 CD63 CLDN11 CLDN19 CLDN8 CLDND2 CLEC2D CMTM5 CNIH3 COL4A5 CXCR2 CYBC1 DOLK EMD ERMP1 FAM20B FAM3C FKBP8 FXYD3 GPR37L1 IER3IP1 LAT LSMEM1 MALL MRAP2 NKG7 PRB1 PTPN9 PTPRN RPRM SERP2 SLC30A8 SLC66A2 SMAGP SMCO4 STATH STX7 SYNGR1 TLCD1 TMEM100 TMEM107 TMEM109 TMEM120B TMEM128 TMEM14A TMEM243 TMEM65 TNFRSF10C TRARG1 TSPAN1 TSPO2 TVP23B VKORC1L1 WNT4
Entrez ID		154807	283232
HPRD ID		12312	14143
Ensembl ID		ENSG00000196715	ENSG00000177042
Uniprot IDs		A8K0F7 Q8N0U8	A0A0A0MTU4 A0AAA9X375 E9PQJ9 Q96HE8
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Retrograde Transporter Complex, Golgi To ER RRNA (guanosine-2'-O-)-methyltransferase Activity Non-motile Cilium Assembly Mitochondrial Translational Initiation RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation Transporter Complex Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport	Membrane Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein Binding
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