SH3D19 and ADAM9

Number of citations of the paper that reports this interaction (PubMedID 15280379)
0

Data Source:
HPRD (in vivo)

		SH3D19	ADAM9
Description		SH3 domain containing 19	ADAM metallopeptidase domain 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Protein Binding Proline-rich Region Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis Positive Regulation Of Membrane Protein Ectodomain Proteolysis	Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Protein Processing Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Amyloid Precursor Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		Golgi Associated Vesicle Biogenesis	Collagen degradation
Drugs			INCB7839
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS			Basophil count ( 32888494)
Interacting Genes		13 interacting genes: ADAM10 ADAM12 ADAM15 ADAM17 ADAM9 CDC42 GRB2 SH3GL1 SH3GL3 SH3RF1 SH3YL1 SOS2 SYNJ1	14 interacting genes: ADAM32 DYRK1A HTRA4 ITGA3 ITGA6 ITGAV MAD2L2 PLEKHA7 PRKCD SCN8A SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		152503	8754
HPRD ID		16364	04091
Ensembl ID		ENSG00000109686	ENSG00000168615
Uniprot IDs		A0A0U1RQE4 A0A494C1M0 Q5HYK7	Q13443
PDB IDs
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Metalloendopeptidase Activity Metallopeptidase Activity Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Integrin-mediated Signaling Pathway Membrane Protein Proteolysis Integrin Binding Regulation Of Cellular Component Organization Peptidase Activity Endocytosis Metallodipeptidase Activity Monocyte Activation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Hydrolase Activity Regulation Of T Cell Chemotaxis Import Into Cell Positive Regulation Of Lymphocyte Chemotaxis Signal Transduction Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Growth Immune System Process Positive Regulation Of Cell Growth Regulation Of Cell Adhesion Focal Adhesion Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Protein Processing Positive Regulation Of T Cell Migration Vesicle Membrane Cell-cell Junction Signaling Receptor Ligand Precursor Processing Positive Regulation Of Lymphocyte Migration Postsynapse Organization Regulation Of Cell Migration Regulation Of Cell Motility Leukocyte Activation Positive Regulation Of Cell Migration Regulation Of T Cell Migration Glutamatergic Synapse Extracellular Matrix Disassembly Presynapse Constitutive Protein Ectodomain Proteolysis Positive Regulation Of Cell Motility Adherens Junction Organization Guanyl-nucleotide Exchange Factor Adaptor Activity	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Integrin Complex Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuregulin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Amide Metabolic Process Cell-cell Adhesion Cell Adhesion Regulation Of Catalytic Activity Insulin-like Growth Factor I Binding Positive Regulation Of Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Cell-matrix Adhesion Protease Binding Filopodium Membrane Positive Regulation Of Phosphate Metabolic Process Cell Surface Regulation Of Membrane Lipid Metabolic Process Negative Regulation Of Lipid Storage Negative Regulation Of Cellular Component Organization Regulation Of Protein Catabolic Process Regulation Of Organelle Organization Regulation Of Apoptotic Signaling Pathway Cell-substrate Adhesion Anchoring Junction Fibronectin Binding Positive Regulation Of Amide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Histone H3T45 Kinase Activity Leukocyte Migration Positive Regulation Of Apoptotic Process Cell Migration Integrin Alpha6-beta4 Complex Regulation Of Lipid Storage Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Positive Regulation Of Phospholipid Scramblase Activity
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