BTLA and CCDC80

		BTLA	CCDC80
Description		B and T lymphocyte associated	coiled-coil domain containing 80
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Matrix
	Molecular Function	Protein Binding Signaling Receptor Activity	Fibronectin Binding Glycosaminoglycan Binding Heparin Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation	Response To Bacterium Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Co-inhibition by BTLA Co-inhibition by BTLA
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Atopic dermatitis ( 23042114) Height ( 31562340) Intracranial aneurysm ( 29531279) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		7 interacting genes: CCDC80 GCSAM PTPN11 PTPN6 TNFRSF14 USF3 VTCN1	1 interacting genes: BTLA
Entrez ID		151888	151887
HPRD ID		06392	10508
Ensembl ID		ENSG00000186265	ENSG00000091986
Uniprot IDs		Q400G7 Q7Z6A9	Q76M96
PDB IDs		2AW2 6NYP 8F60 8F6L 8F6O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Adhesion T Cell Costimulation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Neutrophil Activation Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Neutrophil Activation Involved In Immune Response Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Cell Activation Negative Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cytokine Production Regulation Of Cell Adhesion Mediated By Integrin Myeloid Cell Development Regulation Of Lymphocyte Migration Positive Regulation Of Immune System Process	Adaptive Immune Response Negative Regulation Of Lymphocyte Activation Negative Regulation Of T Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Activation Signaling Receptor Activity Regulation Of Leukocyte Proliferation Negative Regulation Of Cell Activation Negative Regulation Of Cell Adhesion Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Cell-cell Adhesion
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