DTX3L and ANTXR1

Number of citations of the paper that reports this interaction (PubMedID 34285210)
58

Data Source:
BioGRID (two hybrid)

		DTX3L	ANTXR1
Description		deltex E3 ubiquitin ligase 3L	ANTXR cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Lamellipodium Membrane Filopodium Membrane Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Metal Ion Binding Actin Filament Binding
	Biological Process	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Notch Signaling Pathway Endosome To Lysosome Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Binding Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process	Blood Vessel Development Epidermal Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			MDX-1303
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)	Alzheimer's disease ( 30636644) Appendicular lean mass ( 33097823) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Height ( 21998595 31562340) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29235454 29617998 29785010 30054594 31959993) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Periodontitis (stage III/IV grade C) ( 33745150)
Interacting Genes		22 interacting genes: ANTXR1 DTX1 H2AC4 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	10 interacting genes: ASB10 BCL2L1 BRCA1 DTX3L HDAC2 LRP6 RBCK1 RNF182 TRIM35 TRIM51
Entrez ID		151636	84168
HPRD ID		16843	05913
Ensembl ID		ENSG00000163840	ENSG00000169604
Uniprot IDs		Q8TDB6	H0YC24 Q53FL1 Q96EC6 Q9H6X2
PDB IDs		3PG6 8R79	3N2N 6ADL 6ADM 6ADR 6CX1
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Metabolic Process ATP Binding Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Nucleus Proteasomal Protein Catabolic Process ISG15-protein Conjugation Protein Catabolic Process Protein Autoubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cytosol Endosome Membrane Protein K6-linked Ubiquitination Ubiquitin-like Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process SUMO Conjugating Enzyme Activity NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity Nucleoplasm Regulation Of Signal Transduction Protein-containing Complex Global Genome Nucleotide-excision Repair ADP-D-ribose Binding	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Response To Alcohol Ubiquitin-protein Transferase Activity Response To External Biotic Stimulus Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Cycle Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Other Organism Zinc Ion Binding Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Defense Response Response To Stress Apoptotic Process In Bone Marrow Cell Defense Response To Virus Protein Polyubiquitination Positive Regulation Of Male Mating Behavior Histone H4K91 Ubiquitin Ligase Activity Protein Autoubiquitination Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein De-2-hydroxyisobutyrylase Activity Response To Alkaloid Response To Virus Regulation Of Apoptotic Signaling Pathway Enzyme Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Checkpoint Signaling Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Transferase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?