CTSH and CSTB

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CTSH	CSTB
Description		cathepsin H	cystatin B
Image
GO Annotations	Cellular Component	Outer Dense Fiber Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Cytosol Axoneme Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity HLA-A Specific Activating MHC Class I Receptor Activity Kininogen Binding Identical Protein Binding Protein-containing Complex Binding Thyroid Hormone Binding	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Metanephros Development T Cell Mediated Cytotoxicity Adaptive Immune Response Immune Response-regulating Signaling Pathway Proteolysis Apoptotic Process Immune Response Spermatogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Neuropeptide Catabolic Process Bradykinin Catabolic Process Antigen Processing And Presentation Positive Regulation Of Cell Migration Zymogen Activation Protein Destabilization Response To Retinoic Acid Membrane Protein Proteolysis Surfactant Homeostasis Proteolysis Involved In Protein Catabolic Process Dichotomous Subdivision Of Terminal Units Involved In Lung Branching ERK1 And ERK2 Cascade Cellular Response To Thyroid Hormone Stimulus Lysosomal Protein Catabolic Process Response To Odorant Positive Regulation Of Apoptotic Signaling Pathway	Adult Locomotory Behavior Negative Regulation Of Proteolysis
Pathways		MHC class II antigen presentation Surfactant metabolism Neutrophil degranulation	Neutrophil degranulation
Drugs		N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide p-Toluenesulfonic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE	Cupric Chloride
Diseases		Type I diabetes mellitus	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Aspartate aminotransferase levels ( 33547301) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Bipolar disorder ( 21771265) Blood protein levels ( 30072576) Celiac disease ( 30572963) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 24076602 31604244) Narcolepsy ( 23459209) Type 1 diabetes ( 18978792 19430480 25751624 30572963)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		5 interacting genes: BGLAP CSTA CSTB SFTPB XRN1	11 interacting genes: COL6A1 CST3 CTSB CTSD CTSH CTSL ECT2 ERG RAD21 RUNX1 SPRY2
Entrez ID		1512	1476
HPRD ID		00288	03091
Ensembl ID		ENSG00000103811	ENSG00000160213
Uniprot IDs		E9PKT6 P09668	P04080 Q76LA1
PDB IDs		6CZK 6CZS	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?		Response To Testosterone Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Space Peptidase Inhibitor Activity Protease Binding Negative Regulation Of Protein Metabolic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Proteolysis Hydroxyapatite Binding Response To Vitamin K Response To Hydroxyisoflavone Response To Gravity Response To Phenylpropanoid Response To Ketone Regulation Of Testosterone Biosynthetic Process Cellular Response To Zinc Ion Starvation Peptidase Inhibitor Complex Multivesicular Body Lumen Lamellar Body Alveolar Lamellar Body Response To Cycloheximide 5'-3' RNA Exonuclease Activity Response To Alcohol G-quadruplex RNA Binding Response To Macrophage Colony-stimulating Factor G-quadruplex DNA Binding Regulation Of Bone Development 5'-3' Exonuclease Activity Cellular Response To Vitamin D Nuclear MRNA Surveillance Histone MRNA Catabolic Process Regulation Of Proteolysis RRNA Catabolic Process Type B Pancreatic Cell Proliferation Peptide Cross-linking Positive Regulation Of Neurotransmitter Secretion Regulation Of Ketone Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Clathrin-coated Endocytic Vesicle Dendrite Histone MRNA Metabolic Process Response To Vitamin D Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Ficolin-1-rich Granule Lumen Extracellular Matrix Endolysosome Lumen Tertiary Granule Lumen Lysosome Regulation Of Extracellular Matrix Organization Collagen Binding Collagen Metabolic Process Endopeptidase Activity Proteoglycan Binding Antigen Processing And Presentation Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Lung Morphogenesis Peptidase Activity Regulation Of Programmed Cell Death Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Zymogen Activation Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Regulation Of Collagen Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Tissue Regeneration Response To Polyamine Macromolecule Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process ERK1 And ERK2 Cascade HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Developmental Process Antigen Processing And Presentation Of Peptide Antigen Extracellular Exosome Extracellular Region Regulation Of Tissue Remodeling Multicellular Organismal Locomotion Negative Regulation Of Blood Vessel Remodeling Cellular Response To Hormone Stimulus Aspartic-type Peptidase Activity Kininogen Binding Enkephalin Processing Lung Growth Extracellular Space Lysosomal Lumen
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