CTSD and SERPINA4

Number of citations of the paper that reports this interaction (PubMedID 11341921)
0

Data Source:
HPRD (in vitro)

		CTSD	SERPINA4
Description		cathepsin D	serpin family A member 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process
Pathways		Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression	Platelet degranulation Developmental Lineage of Pancreatic Acinar Cells
Drugs		S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE	Zinc Copper Zinc acetate
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Blood protein levels ( 30072576) Vaspin levels ( 22907691)
Interacting Genes		25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG	15 interacting genes: CFTR CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 TRIP11 YAE1
Entrez ID		1509	5267
HPRD ID		00291	01004
Ensembl ID		ENSG00000117984	ENSG00000100665
Uniprot IDs		P07339 V9HWI3	A0A024R6I9 P29622
PDB IDs		1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9	6F02
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis
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