HSCB and BBS2

Number of citations of the paper that reports this interaction (PubMedID 18000879)
0

Data Source:
BioGRID (two hybrid)

		HSCB	BBS2
Description		HscB mitochondrial iron-sulfur cluster cochaperone	Bardet-Biedl syndrome 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	ATPase Activator Activity Molecular_function Protein Binding Identical Protein Binding Metal Ion Binding Protein-folding Chaperone Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Protein Complex Oligomerization Primitive Hemopoiesis Primitive Erythrocyte Differentiation	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Complex I biogenesis Complex III assembly	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Breast size ( 27182965) Diastolic blood pressure ( 27841878) Esophageal cancer and gastric cancer ( 20729852) Mean platelet volume ( 32888494) Myeloproliferative neoplasms ( 33057200) Pancreatic cancer ( 25086665) Red cell distribution width ( 27863252) Systolic blood pressure ( 27841878) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: AGTRAP BBS1 BBS2 BBS4 FBN1	27 interacting genes: APOC2 BHMT CES1 CETP CNOT1 EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B GOT2 HNRNPF HSCB HSF4 KCNK17 KRT18 LMO4 MAP2K5 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS SPTSSA UBC WRNIP1
Entrez ID		150274	583
HPRD ID		16289	05855
Ensembl ID		ENSG00000100209	ENSG00000125124
Uniprot IDs		B0QYH2 Q8IWL3	A0A804HIE1 A0A804HKG1 Q9BXC9
PDB IDs		3BVO
Enriched GO Terms of Interacting Partners?		BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Regulation Of Response To Food Brain Morphogenesis Regulation Of Appetite Regulation Of Response To Nutrient Levels Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Leptin-mediated Signaling Pathway Fat Cell Differentiation Centriolar Satellite Animal Organ Morphogenesis Negative Regulation Of Appetite Adult Behavior Retina Homeostasis Response To Leptin Visual Perception Sensory Perception Of Light Stimulus Ventricular System Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Motile Cilium Melanosome Localization Pigment Granule Localization Regulation Of Microtubule-based Process Cilium Assembly Positive Regulation Of Multicellular Organism Growth Golgi To Plasma Membrane Protein Transport Gene Expression Cilium Organization Dendrite Development Regulation Of Biological Quality Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cilium Golgi To Plasma Membrane Transport Maintenance Of Protein Location Regulation Of Multicellular Organism Growth Microtubule Cytoskeleton Organization	Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center
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