CTNND1 and EIF4G3

Number of citations of the paper that reports this interaction (PubMedID 35780119)
58

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		CTNND1	EIF4G3
Description		catenin delta 1	eukaryotic translation initiation factor 4 gamma 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Catenin Complex Midbody Ciliary Basal Body Extracellular Exosome Anchoring Junction	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Phosphatase Inhibitor Activity Phosphatase Binding Cadherin Binding Cell-cell Adhesion Mediator Activity Protein Sequestering Activity	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Negative Regulation Of D-glucose Transmembrane Transport Wnt Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Intracellular Signal Transduction D-glucose Transmembrane Transport Negative Regulation Of Blood Vessel Branching	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Spermatid Development Negative Regulation Of Autophagy Positive Regulation Of Translation
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		36 interacting genes: ACTA1 APP CDH1 CDH11 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR EIF4A3 EIF4G3 ERBIN FER GRIK2 GSK3B JUP KCTD6 MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RNF26 RPS6KA3 SMURF1 SNCA SRC SUMO2 WEE2-AS1 YWHAG ZBTB33	17 interacting genes: CAMK1 CTNND1 DDX19B EIF4A1 EIF4E HSPB1 LIG4 LSM3 MKNK1 PABPC1 PCNT PSMB6 RNF10 TRIM25 VAV2 VPS25 WDR37
Entrez ID		1500	8672
HPRD ID		03026	06802
Ensembl ID		ENSG00000198561	ENSG00000075151
Uniprot IDs		O60716	A0A0A0MSA7 A0A804HJV5 A0A8I5QJH9 A0A8J9G7U8 B4DXR2 O43432 Q59GJ0
PDB IDs		3L6X 3L6Y	1HU3
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell Adhesion Cell Junction Organization Regulation Of Multicellular Organismal Process Cell Junction Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Beta-catenin Binding Regulation Of Signal Transduction Regulation Of Locomotion Cell Junction Assembly Negative Regulation Of Signaling Negative Regulation Of Cell Communication Adherens Junction Cell-cell Adhesion Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Postsynapse Adherens Junction Organization Plasma Membrane Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Cell Migration Cell-cell Junction Assembly Regulation Of Cell Motility Cell-cell Junction Positive Regulation Of Metabolic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Locomotion Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cell-cell Junction Organization Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Positive Regulation Of Cell Migration Developmental Process Glutamatergic Synapse Regulation Of Metabolic Process Regulation Of Synaptic Plasticity Epidermal Growth Factor Receptor Signaling Pathway	Cytoplasmic Stress Granule Nucleus Cytoplasm RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Extracellular Exosome RNA Binding Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Translation
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