CTBP1 and IKZF2

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		CTBP1	IKZF2
Description		C-terminal binding protein 1	IKAROS family zinc finger 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleus
	Molecular Function	Transcription Coregulator Binding Transcription Corepressor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Viral Genome Replication Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Synaptic Vesicle Endocytosis White Fat Cell Differentiation Regulation Of Cell Cycle Synaptic Vesicle Clustering	Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants Negative Regulation of CDH1 Gene Transcription
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	C-reactive protein levels ( 30388399) Eosinophil count ( 19198610 32888494 27863252 29403010) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31451708) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Selective IgA deficiency ( 27723758) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systemic sclerosis ( 29293537) Type 2 diabetes ( 32499647)
Interacting Genes		101 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CCDC9 CDC23 CDKN2D CEP68 CHD3 CPSF7 CREBBP CRY2 CTBP2 CTNNA1 DCAF6 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FUNDC1 GNL3L GTF2B H2AX H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KLF12 LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PKP2 PLCB1 PNN PRKAA1 PRKCI PRPF19 PRPF6 PRRC2B RAI2 RB1 RBBP5 RBBP8 RBM14 RBM22 RIPK4 RNF111 SART3 SF1 SIN3A SNRPN SNW1 SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 TSHZ3 UNKL ZBP1 ZEB1 ZEB2 ZFPM2 ZNF219 ZNF750	11 interacting genes: AQP1 CFTR CTBP1 CTBP2 HDAC4 IKZF1 IKZF4 IKZF5 LONRF1 SPAG16 TCEANC
Entrez ID		1487	22807
HPRD ID		04015	05872
Ensembl ID		ENSG00000159692	ENSG00000030419
Uniprot IDs		H0Y8U5 Q13363 X5D8Y5	B4DWF2 Q9UKS7
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR 6V89 6V8A 7KWM 8ARI	7LPS 8DEY
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone Deacetylase Complex Chromatin Remodeling Nuclear Speck RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Organization Negative Regulation Of Metabolic Process Protein Lysine Deacetylase Activity Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Response To Stress Histone Deacetylase Activity Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Binding Nucleic Acid Metabolic Process Transcription Coactivator Activity	Transepithelial Water Transport Protein Domain Specific Binding Transcription Repressor Complex Epithelial Fluid Transport Negative Regulation Of DNA-templated Transcription White Fat Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Viral Genome Replication Negative Regulation Of RNA Metabolic Process Water Transport Multicellular Organismal-level Water Homeostasis Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Fluid Transport Transepithelial Transport NAD Binding Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Cellular Response To CAMP Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Corepressor Binding Multicellular Organismal-level Chemical Homeostasis Protein-containing Complex Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Positive Regulation Of Anion Channel Activity Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To CAMP Positive Regulation Of Saliva Secretion Odontogenesis Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Monoatomic Anion Transport Axonemal Central Apparatus Regulation Of RNA Metabolic Process Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Hydrogen Peroxide Transmembrane Transport
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