CIROZ and NPHP4

		CIROZ	NPHP4
Description		ciliated left-right organizer protein containing ZP-N domains	nephrocystin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cilium Nuclear Body Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Anchoring Junction Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium
	Molecular Function		Structural Molecule Activity Protein Binding
	Biological Process	Establishment Of Left/right Asymmetry	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone
Pathways			Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS			Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (paclitaxel) ( 23006423)
Interacting Genes		1 interacting genes: NPHP4	8 interacting genes: CIROZ EDIL3 FBXO44 NPHP1 RBP7 RPGRIP1 SCRG1 TMEM201
Entrez ID		148345	261734
HPRD ID		08780	06238
Ensembl ID		ENSG00000175262	ENSG00000131697
Uniprot IDs		Q8N9H9	B3KW36 O75161
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Ciliary Transition Zone Ribbon Synapse Photoreceptor Distal Connecting Cilium Positive Regulation Of Bicellular Tight Junction Assembly Photoreceptor Cell Outer Segment Organization Regulation Of Bicellular Tight Junction Assembly Photoreceptor Connecting Cilium Ciliary Transition Zone Photoreceptor Cell Maintenance Non-motile Cilium Ciliary Base Visual Behavior Protein Localization To Cilium Retina Development In Camera-type Eye Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Positive Regulation Of Cell Junction Assembly Bicellular Tight Junction Sperm Motility Cilium-dependent Cell Motility Negative Regulation Of Canonical Wnt Signaling Pathway Structural Molecule Activity Cilium Movement Centriole Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly	Photoreceptor Connecting Cilium
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