ZNF420 and CYP4V2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF420	CYP4V2
Description		zinc finger protein 420	cytochrome P450 family 4 subfamily V member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding Long-chain Fatty Acid Omega-hydroxylase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Retinoid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Visual Perception Fatty Acid Omega-oxidation Sterol Metabolic Process
Pathways		Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Endogenous sterols The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases			Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Plateletcrit ( 32888494) Prudent dietary pattern ( 28644415) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cardiac troponin-I levels ( 31014085) Cerebral amyloid deposition (PET imaging) ( 30361487) L-arginine levels ( 27656708) Metabolite levels ( 22916037) Serum metabolite concentrations in chronic kidney disease ( 33838163) Venous thromboembolism ( 30659681)
Interacting Genes		15 interacting genes: AIRIM CDC42 CDK2AP1 CDKN2A CEP19 CYP4V2 CYP51A1 EXOSC5 HAX1 KRTAP10-7 MDM2 SLC1A7 TNFRSF1B TRIM28 ZNF76	2 interacting genes: MTDH ZNF420
Entrez ID		147923	285440
HPRD ID		08122	16777
Ensembl ID		ENSG00000197050	ENSG00000145476
Uniprot IDs		Q8TAQ5	Q6ZWL3
PDB IDs
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Protein Sumoylation Regulation Of Establishment Of Protein Localization Regulation Of Nucleocytoplasmic Transport Heart Valve Development Disordered Domain Specific Binding Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Regulation Of Protein Localization Ligase Inhibitor Activity Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Response To Formaldehyde Cellular Response To Vitamin B1 Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Protein Destabilization Euchromatin Regulation Of Transport GBD Domain Binding Storage Vacuole P53 Binding Cellular Response To Hydrogen Peroxide Regulation Of Intracellular Transport Monooxygenase Activity Positive Regulation Of Nucleocytoplasmic Transport Extracellularly Glutamate-gated Chloride Channel Activity Krueppel-associated Box Domain Binding
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