SPC24 and SKA3

Number of citations of the paper that reports this interaction (PubMedID 22371557)
46

Data Source:
BioGRID (two hybrid, two hybrid)

		SPC24	SKA3
Description		SPC24 component of NDC80 kinetochore complex	spindle and kinetochore associated complex subunit 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Ndc80 Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Mitotic Spindle Meiotic Spindle SKA Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Microtubule Binding
	Biological Process	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) Haemorrhoidal disease ( 33888516) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298)
Interacting Genes		7 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SUOX WHRN	6 interacting genes: APP AURKB LRRK2 NDC80 SPC24 ZDHHC17
Entrez ID		147841	221150
HPRD ID		15464	10706
Ensembl ID		ENSG00000161888	ENSG00000165480
Uniprot IDs		Q8NBT2	Q8IX90
PDB IDs		2VE7 3IZ0 8PPR 8Q5H	4AJ5
Enriched GO Terms of Interacting Partners?		SKA Complex Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Outer Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Meiotic Spindle Organization Kinetochore Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Spindle Microtubule Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Nuclear Chromosome Segregation Establishment Of Spindle Localization Metaphase Chromosome Alignment Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Spindle Localization Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Mitotic Cell Cycle Meiotic Spindle Organelle Localization Chromosome Segregation Mitotic Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Spindle Organization Chromosome, Centromeric Region Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Spindle Establishment Of Localization In Cell Microtubule Binding Regulation Of Microtubule-based Process Establishment Of Organelle Localization Membraneless Organelle Assembly Microtubule-based Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Chromosome Organization Microtubule Regulation Of Mitotic Sister Chromatid Separation Synaptic Membrane	Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Sister Chromatid Separation Ndc80 Complex Regulation Of Chromosome Separation Cellular Response To Manganese Ion Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Intracellular Signal Transduction Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Cellular Component Organization Response To Manganese Ion Regulation Of Chromosome Segregation Regulation Of Mitotic Cell Cycle Regulation Of Nuclear Division Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Response To Catecholamine Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Positive Regulation Of Cell Cycle Checkpoint Outer Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Binding Neuron Projection Morphogenesis Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Nuclear Division Cell Projection Morphogenesis Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Regulation Of Synapse Organization Regulation Of Intracellular Signal Transduction Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Cell Cycle
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