CCBE1 and TOX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CCBE1	TOX4
Description		collagen and calcium binding EGF domains 1	TOX high mobility group box family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix	Chromosome, Telomeric Region Chromatin Nucleus Chromosome PTW/PP1 Phosphatase Complex
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Collagen Binding	DNA Binding Protein Binding Chromatin DNA Binding
	Biological Process	Angiogenesis Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Respiratory Gaseous Exchange By Respiratory System Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Lung Development Endothelial Cell Migration Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis Lymphatic Endothelial Cell Migration	RNA Polymerase II Promoter Clearance Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Appendicular lean mass ( 33097823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23857890) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pre-treatment viral load in HIV-1 infection ( 31219150) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		12 interacting genes: CEP55 COPS6 FBXO7 FXR1 INCA1 KLHL12 KRT27 KRT36 LNX1 SIAH2 STX11 TOX4	16 interacting genes: ATXN1 BANP CCBE1 CREB1 EXOSC10 FNDC3B GEMIN6 HIPK3 HSPB1 MYL7 PPP1CA QRICH1 TBX6 WDR82 ZMYND19 ZNF512B
Entrez ID		147372	9878
HPRD ID		08703	12661
Ensembl ID		ENSG00000183287	ENSG00000092203
Uniprot IDs		A0A8Q3WKU1 Q6UXH8	O94842
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Skin Epidermis Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Intermediate Filament Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin-like Ligase-substrate Adaptor Activity Lewy Body Core	RNA Polymerase II Promoter Clearance PTW/PP1 Phosphatase Complex RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Glial Cell Proliferation Chemotaxis To Arachidonate RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Protein Kinase C Signaling RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transforming Growth Factor Beta3 Production Visual Behavior Nucleic Acid Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription Euchromatin RNA Binding Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Positive Regulation Of DNA-templated Transcription, Elongation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Transcription By RNA Polymerase II Response To Dehydroepiandrosterone Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process
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