DNAH2 and KCTD11

		DNAH2	KCTD11
Description		dynein axonemal heavy chain 2	potassium channel tetramerization domain containing 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection 9+2 Motile Cilium	Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Transferase Activity Identical Protein Binding
	Biological Process	Microtubule-based Movement Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Smoothened Signaling Pathway Nervous System Development Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Neuroblast Differentiation Protein Ubiquitination Neuron Differentiation Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 27863252) Red blood cell count ( 32888494) Uterine fibroids ( 30194396) White blood cell count ( 27863252 32888494)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		7 interacting genes: CCDC42 CDK18 KCTD11 KRABD2 LINC01554 ODF4 PIK3R6	4 interacting genes: CUL3 DNAH2 HDAC1 KCTD15
Entrez ID		146754	147040
HPRD ID		17214	13763
Ensembl ID		ENSG00000183914	ENSG00000213859
Uniprot IDs		Q9P225	A0A158RFT7 Q693B1
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?			Hair Follicle Placode Formation Transcription Corepressor Activity Krueppel-associated Box Domain Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Sperm Flagellum Regulation Protein Catabolic Process At Postsynapse Trophectodermal Cellular Morphogenesis POZ Domain Binding Motile Cilium Liver Morphogenesis Polar Microtubule Inner Dynein Arm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-containing Complex Assembly Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Myotube Differentiation Host-mediated Suppression Of Viral Transcription Histone Deacetylase Activity Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Eyelid Development In Camera-type Eye Sin3-type Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Animal Organ Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation NuRD Complex Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Cell Fate Specification Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Rho Protein Signal Transduction Renal Sodium Ion Transport Positive Regulation Of Mitotic Sister Chromatid Separation Protein-containing Complex Organization Embryonic Cleavage Notch Binding Ubiquitin Ligase Complex Scaffold Activity Cullin-RING Ubiquitin Ligase Complex Contractile Actin Filament Bundle Assembly
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