CSF2RB and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 11551900)
0

Data Source:
HPRD (in vitro, in vivo)

		CSF2RB	MAD2L1
Description		colony stimulating factor 2 receptor subunit beta	mitotic arrest deficient 2 like 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Mitotic Checkpoint Complex Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Regulation Of Nuclear Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Sargramostim NPI 32101 Resatorvid
Diseases
GWAS		Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Coronary artery disease ( 28714974 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369) Myocardial infarction ( 33532862) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	26 interacting genes: ADAM17 ANAPC2 APP BBS7 CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		1439	4085
HPRD ID		00739	03274
Ensembl ID		ENSG00000100368	ENSG00000164109
Uniprot IDs		P32927 Q6NSJ8	Q13257
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response	Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Nuclear Division Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex Regulation Of Cell Cycle Process Regulation Of Meiotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Metaphase/anaphase Transition Of Cell Cycle Cell Division Regulation Of Reproductive Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Phase Transition Spindle Negative Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint PTB Domain Binding Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cell Cycle Meiotic Cell Cycle Phase Transition Zeta DNA Polymerase Complex Negative Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Growth
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