MUC15 and CD3E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MUC15	CD3E
Description		mucin 15, cell surface associated	CD3 epsilon subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Membrane	Immunological Synapse Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process		Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of T Cell Anergy T Cell Anergy Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Calcium-mediated Signaling Cerebellum Development T Cell Costimulation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation Lymphocyte Activation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein-containing Complex Assembly Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1
Drugs			Muromonab Teplizumab Catumaxomab Mosunetuzumab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Exhaled nitric oxide levels ( 28109725) Exhaled nitric oxide output ( 28109725) Obesity (extreme) ( 19553259)	Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		2 interacting genes: CD3E CNR2	28 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK DRD2 EPS8L1 LCK MUC15 NAT8 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1
Entrez ID		143662	916
HPRD ID		16349	08923
Ensembl ID		ENSG00000169550	ENSG00000198851
Uniprot IDs		A0A0A0MT67 A0A0A0MTD6 Q8N387	P07766
PDB IDs			1A81 1SY6 1XIW 2ROL 5QU2 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8F0L 8JC0 8JCB 8TW4 8TW6 8VY4 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Anergy Alpha-beta T Cell Receptor Complex Signal Complex Assembly Positive Regulation Of Tolerance Induction Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Thymic T Cell Selection T Cell Receptor Binding T Cell Tolerance Induction Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of T Cell Anergy Negative Thymic T Cell Selection Negative T Cell Selection CD4-positive, Alpha-beta T Cell Proliferation T Cell Anergy Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Tolerance Induction Regulation Of Cell Activation Gamma-delta T Cell Receptor Complex Regulation Of T Cell Tolerance Induction Cannabinoid Receptor Activity Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Trans-synaptic Signaling, Modulating Synaptic Transmission Cannabinoid Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Mast Cell Activation Positive T Cell Selection Alpha-beta T Cell Proliferation G Protein-coupled Receptor Signaling Pathway Regulation Of Tolerance Induction Tolerance Induction T Cell Receptor Complex Regulation Of Mast Cell Activation Gamma-delta T Cell Activation Thymic T Cell Selection Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-4 Production T Cell Selection Response To Amphetamine Signaling Receptor Complex Adaptor Activity Regulation Of Interleukin-4 Production Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Interleukin-2 Production Negative Regulation Of Synaptic Transmission Immune Response Dendrite Development	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Complex Lymphocyte Activation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Activation Regulation Of Immune Response T Cell Activation Cell Activation Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Adaptive Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune Response Lymphocyte Differentiation Alpha-beta T Cell Receptor Complex T Cell Selection Negative Regulation Of T Cell Receptor Signaling Pathway Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mononuclear Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Thymic T Cell Selection T Cell Receptor Binding Positive T Cell Selection Leukocyte Differentiation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Gamma-delta T Cell Activation T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Beta Selection Immune Response Regulation Of Cell-cell Adhesion B Cell Activation Positive Regulation Of Cell-cell Adhesion
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