CRYBA1 and KLK10

		CRYBA1	KLK10
Description		crystallin beta A1	kallikrein related peptidase 10
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Phagocytosis Visual Perception Regulation Of Autophagy Negative Regulation Of TOR Signaling Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis	Proteolysis Protein Maturation
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mean reticulocyte volume ( 32888494) Night sleep phenotypes ( 27126917)	Blood protein levels ( 30072576)
Interacting Genes		33 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CPD CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 EVI2A EVI2B FBXO3 FOXH1 HOXC8 KLK10 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NF1 NOXA1 OMG PLEKHF2 PROP1 RBPMS RHOXF2 SPRR1B TAF15 VAC14 YPEL3	3 interacting genes: BCAP31 CRYBA1 LRIF1
Entrez ID		1411	5655
HPRD ID		00429	04054
Ensembl ID		ENSG00000108255	ENSG00000129451
Uniprot IDs		P05813	O43240 Q6ICR6
PDB IDs			5LPE 5LPF
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Structural Molecule Activity Tubulin Complex Assembly Negative Regulation Of Intracellular Transport	Positive Regulation Of Anoikis Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Structural Constituent Of Eye Lens Protein Localization To Endoplasmic Reticulum Exit Site MHC Class I Protein Binding Positive Regulation Of ERAD Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Retrograde Protein Transport, ER To Cytosol Perinuclear Endoplasmic Reticulum Positive Regulation Of Protein Exit From Endoplasmic Reticulum Sex-chromosome Dosage Compensation Barr Body Nuclear Retinoic Acid Receptor Binding Dosage Compensation By Inactivation Of X Chromosome Regulation Of Anoikis Regulation Of ERAD Pathway Lumenal Side Of Endoplasmic Reticulum Membrane Protein Targeting To Mitochondrion
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