SUN5 and NIN

		SUN5	NIN
Description		Sad1 and UNC84 domain containing 5	ninein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Golgi Apparatus Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Sperm Head-tail Coupling Apparatus	Pericentriolar Material Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Axon Dendrite Ciliary Basal Body Axonal Growth Cone Apical Part Of Cell Mitotic Spindle Mitotic Spindle Pole Ciliary Transition Fiber Centriolar Subdistal Appendage
	Molecular Function	Protein Binding Protein-membrane Adaptor Activity	Nucleotide Binding Calcium Ion Binding Protein Binding GTP Binding Microtubule Minus-end Binding
	Biological Process	Spermatogenesis Spermatid Development Cell Differentiation	Intracellular Protein Localization Centriole-centriole Cohesion Corpus Callosum Morphogenesis Corticospinal Tract Morphogenesis Microtubule Anchoring At Centrosome Collateral Sprouting Positive Regulation Of Axonogenesis Centrosome Localization Centrosome-templated Microtubule Nucleation
Pathways
Drugs
Diseases
GWAS		Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025) Cognitive performance ( 20125193) Diastolic blood pressure ( 30578418) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Rectal cancer ( 33632709) Refractive error ( 32231278) Schizophrenia ( 33169155) Stroke ( 32693751) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: APP NIN SPAG4 UBC	24 interacting genes: ABI1 ATL1 AUNIP AURKA BICD1 COCH EIF4ENIF1 GSK3B GTSE1 KLC1 L2HGDH NPTX2 PIAS1 PRKACA PRPF6 RBM10 RTRAF SNW1 SUMO1 SUN5 TXNDC16 UBE2I UTP14A YWHAE
Entrez ID		140732	51199
HPRD ID		15422	09785
Ensembl ID		ENSG00000167098	ENSG00000100503
Uniprot IDs		A0A384MDU5 A9Z1W8 Q8TC36	C9J066 E9PN67 Q5XUU0 Q8N4C6
PDB IDs
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Centrosome-templated Microtubule Nucleation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Microtubule Nucleation By Microtubule Organizing Center Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Corticospinal Tract Morphogenesis Corpus Callosum Morphogenesis Cell Projection Morphogenesis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Ciliary Transition Fiber Peptidase Activator Activity Cellular Response To Manganese Ion Centriolar Subdistal Appendage Meiotic Nuclear Membrane Microtubule Tethering Complex Antifungal Humoral Response	Regulation Of Nucleocytoplasmic Transport Nuclear Speck Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Small Protein Activating Enzyme Binding PML Body Centrosome Peptidyl-serine Phosphorylation Regulation Of Intracellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome Regulation Of Intracellular Protein Transport Cellular Response To Heat Protein Sumoylation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Processing Regulation Of Protein Localization To Centrosome RNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Localization To Organelle Dynactin Binding Positive Regulation Of Protein Catabolic Process Enzyme Binding Response To Heat Positive Regulation Of Intracellular Protein Transport Intracellular Potassium Ion Homeostasis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Transcription Factor Binding SUMO Transferase Activity Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Metabolic Process Regulation Of Cellular Localization Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Protein Metabolic Process Nuclear Export Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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