CRKL and KIDINS220

Number of citations of the paper that reports this interaction (PubMedID 15167895)
43

Data Source:
HPRD (in vitro, in vivo)

		CRKL	KIDINS220
Description		CRK like proto-oncogene, adaptor protein	kinase D interacting substrate 220
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane	Endosome Late Endosome Cytosol Membrane Protein-containing Complex
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Protein Kinase Regulator Activity PDZ Domain Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	In Utero Embryonic Development Nervous System Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	ARMS-mediated activation ARMS-mediated activation RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)	Alcoholic chronic pancreatitis ( 28754779) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)
Interacting Genes		79 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CHEK2 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1	13 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 RBX1 SEPTIN5
Entrez ID		1399	57498
HPRD ID		03596	17235
Ensembl ID		ENSG00000099942	ENSG00000134313
Uniprot IDs		P46109	A0A8I5QJC0 Q9ULH0
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation	Neurotrophin Binding Neurotrophin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Circadian Rhythm Cellular Developmental Process Positive Regulation Of Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Signal Transduction Response To Nerve Growth Factor Nerve Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Neuron Projection Development GPI-linked Ephrin Receptor Activity Positive Regulation Of Synapse Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Postsynaptic Specialization Assembly Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Action Potential Propagation Neuronal Action Potential Propagation Cell Death Programmed Cell Death Rhythmic Process B Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Nervous System Development System Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Positive Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization
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