SPANXN3 and ATP6V1C2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPANXN3	ATP6V1C2
Description		SPANX family member N3	ATPase H+ transporting V1 subunit C2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Proton Transmembrane Transporter Activity Identical Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process		Monoatomic Ion Transport Regulation Of Macroautophagy Positive Regulation Of Wnt Signaling Pathway Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Creatine kinase levels ( 29403010)	Cardiac Troponin-T levels ( 23247143)
Interacting Genes		17 interacting genes: APP ATP6V1C2 CAVIN1 CEP70 FAM217B FAM228A HAND2 MEOX2 NEDD4 PBX4 PTGES3L-AARSD1 SDCBP SP4 STAC3 YAF2 ZNF143 ZNF76	7 interacting genes: GOLGA2 KLHL24 KRTAP12-2 MEOX2 PAX6 REL SPANXN3
Entrez ID		139067	245973
HPRD ID		18092	16523
Ensembl ID		ENSG00000189252	ENSG00000143882
Uniprot IDs		Q5MJ09	A0A0U1RR16 Q8NEY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Frizzled Binding Positive Regulation Of DNA-templated Transcription Identical Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of RNA Metabolic Process Membrane Raft
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