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CREB1 and CDK1
Number of citations of the paper that reports this interaction (PubMedID
23814058
)
52
Data Source:
BioGRID
(enzymatic study, enzymatic study)
CREB1
CDK1
Description
cAMP responsive element binding protein 1
cyclin dependent kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Mitochondrial Matrix
Centrosome
Cytosol
Axon
Ciliary Basal Body
RNA Polymerase II Transcription Regulator Complex
ATF4-CREB1 Transcription Factor Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Cyclin B1-CDK1 Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Hsp70 Protein Binding
Histone Acetyltransferase Binding
CAMP Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Arrestin Family Protein Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
Virus Receptor Activity
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
Cyclin Binding
Hsp70 Protein Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Protein Serine Kinase Activity
Biological Process
Response To Hypoxia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Axonogenesis
Lactation
Memory
Circadian Rhythm
Regulation Of Cell Size
Visual Learning
Response To Xenobiotic Stimulus
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription By Competitive Promoter Binding
Response To Purine-containing Compound
Response To Activity
Pituitary Gland Development
Cell Differentiation
Osteoclast Differentiation
Mammary Gland Development
Positive Regulation Of Transforming Growth Factor Beta3 Production
Secretory Granule Organization
Response To Glucagon
Chemotaxis To Arachidonate
Response To Nicotine
Cellular Response To Hepatocyte Growth Factor Stimulus
Response To Erythropoietin
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Multicellular Organism Growth
Response To Cocaine
MRNA Transcription By RNA Polymerase II
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Morphine
Response To Ethanol
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Hormone Secretion
Positive Regulation Of Hormone Secretion
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Fibroblast Proliferation
Rhythmic Process
Protein Stabilization
Positive Regulation Of Cardiac Muscle Tissue Development
Regulation Of Glial Cell Proliferation
Lung Epithelium Development
Lung Saccule Development
Type I Pneumocyte Differentiation
Cellular Response To Zinc Ion
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Cellular Response To Fatty Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
CAMP/PKA Signal Transduction
Positive Regulation Of Long-term Synaptic Potentiation
Response To L-glutamate
Response To Dehydroepiandrosterone
Positive Regulation Of Membrane Depolarization
Cellular Response To Forskolin
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Leukemia Inhibitory Factor
Response To Hypobaric Hypoxia
Regulation Of Testosterone Biosynthetic Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Pronuclear Fusion
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Response To Amine
Response To Activity
Cell Migration
Protein Deubiquitination
Peptidyl-threonine Phosphorylation
Chromosome Condensation
Epithelial Cell Differentiation
Protein Localization To Kinetochore
Positive Regulation Of Protein Import Into Nucleus
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Mitotic Cell Cycle Phase Transition
Response To Ethanol
Positive Regulation Of DNA Replication
Regulation Of Embryonic Development
Thymidine Biosynthetic Process
Response To Cadmium Ion
Response To Copper Ion
Symbiont Entry Into Host Cell
Microtubule Polymerization
Fibroblast Proliferation
Rhythmic Process
Response To Axon Injury
Cell Division
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cilium Disassembly
Positive Regulation Of Mitotic Sister Chromatid Segregation
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Golgi Disassembly
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Cytoskeleton Organization Involved In Mitosis
DNA Synthesis Involved In Mitotic DNA Replication
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Protein Localization To Site Of Double-strand Break
Mitotic DNA-templated DNA Replication
Pathways
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerization of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
PKR-mediated signaling
Drugs
Adenosine phosphate
Naloxone
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Avotaciclib
Diseases
GWAS
Body mass index (
25673413
28892062
)
Diastolic blood pressure (
27841878
)
Food antigen IgG levels (
24962563
)
Mean corpuscular hemoglobin (
32888494
)
Refractive error (
32231278
)
Systolic blood pressure (
27841878
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
87 interacting genes:
ABL1
AGR2
AKT1
ATF1
ATF6
ATF7IP
ATM
ATR
BRD10
CAMK2A
CCDC6
CD274
CDK1
CEBPB
CHD3
CHD8
CREBBP
CREM
CRTC1
CRTC2
CSNK1D
CSNK2A1
CSNK2B
DNMT3L
DYRK1A
EDF1
ERG28
ETS1
FHL5
GLI2
GSK3A
GSK3B
GTF2A1
GTF2F2
HIPK3
HIVEP1
HNF1B
HPS6
KAT5
KCNIP3
MAPK14
MAPKAPK2
MTF2
NR3C1
PDX1
PIAS1
PIAS2
POGZ
POU2F1
PPP1CA
PRKACA
PRKG1
PTEN
RAB1A
RBBP4
RECQL5
RFX3
RGS13
RNF111
RNF4
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
SGK1
SMARCA4
SMARCA5
SMCO1
SOX9
SRA1
SREBF2
SRF
SUZ12
THRA
TOX4
TRIM22
TSSK4
UBE2I
VIM
YY1
ZHX1
ZMYM2
ZNF35
ZNF436
ZNF451
ZNF92
243 interacting genes:
ABL1
ACSL4
ADD1
AKAP12
AKT1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BCL2L11
BIRC5
BIRC6
BRCA1
BRCA2
BTG2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDCA2
CDCA5
CDK7
CDKN1A
CDKN3
CDT1
CEBPA
CENPF
CEP55
CEP63
CHAF1B
CIITA
CIP2A
CKS2
CNOT7
CREB1
CREM
CSN2
CSNK2A1
CSNK2B
CTNNB1
CUL4B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EML3
EPN1
ERCC2
ERCC6L
FANCA
FANCC
FANCG
FBXO5
FEN1
FLNA
FOXM1
FOXO1
FYN
GADD45A
GADD45B
GADD45G
GAS2L3
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HASPIN
HJURP
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
ID2
IDH1
IDH2
IL16
IL3RA
IPO13
IQGAP1
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LRRK1
LYN
LZTS1
MAP4
MAPK12
MAPT
MBP
MCM2
MCM4
MDM4
MEF2C
MIS18BP1
MISP
MKI67
MLKL
MLST8
MNDA
MYC
MYT1
NCAPD2
NCAPD3
NCAPG
NCAPH
NCL
NDE1
NEDD1
NES
NHERF1
NONO
NPM1
NSFL1C
NUP210
PAK6
PBK
PCM1
PCNA
PIN1
PIP5K1C
PITPNM1
PKMYT1
PLEC
PML
POLA1
POLL
PON1
PPP1R12A
PPP2R1A
PPP2R1B
PPP2R2B
PPP4R2
PPP4R3A
PRC1
PRDX1
PRDX2
PRKAR2A
PSRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAD9A
RANGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RFX3
RGCC
RPA2
RPS3
RPS6KB1
RRM2
RSF1
RUNX1
RUNX2
SAMHD1
SFN
SLBP
SOX2
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TERF1
TFDP1
TGFBR2
TK1
TLE1
TMPO
TNNC1
TOP2A
TP53
TP53BP1
TP73
TPR
TSC1
TSPYL2
TUBB
UBA1
UBE2A
UBE3A
UHRF2
USP14
USP16
VHL
VIM
WAC
WEE1
XIAP
XPO1
XRCC6
ZBTB16
Entrez ID
1385
983
HPRD ID
00442
00302
Ensembl ID
ENSG00000118260
ENSG00000170312
Uniprot IDs
B7Z5C6
P16220
Q53X93
Q5U0J5
B7Z3D6
I6L9I5
P06493
PDB IDs
2LXT
5ZK1
5ZKO
7TBH
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
6TWN
7NJ0
Enriched GO Terms of Interacting Partners
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Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nucleoplasm
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Serine/threonine Kinase Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Serine Kinase Activity
Protein Kinase Activity
PML Body
Kinase Activity
Chromatin
DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
ATP Binding
Transferase Activity
Chromatin Remodeling
Phosphorylation
Cellular Response To Oxygen-containing Compound
Cellular Response To Stress
Positive Regulation Of CREB Transcription Factor Activity
DNA-binding Transcription Factor Activity
Chromatin Organization
Sequence-specific DNA Binding
Nucleic Acid Metabolic Process
Intracellular Signal Transduction
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Cell Division
Nucleus
Cellular Response To Stress
Nucleoplasm
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Organelle Organization
Cytosol
Cytoplasm
Regulation Of Cell Cycle Phase Transition
Chromosome
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Chromosome Organization
DNA Metabolic Process
Response To Stress
Negative Regulation Of Macromolecule Metabolic Process
DNA Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cytoskeleton
Regulation Of DNA Metabolic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Cell Cycle Process
Positive Regulation Of Apoptotic Process
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Cell Cycle G2/M Phase Transition
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Signal Transduction
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Component Assembly
Negative Regulation Of Mitotic Cell Cycle
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Tagcloud (Intersection)
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