CR1 and CD55

Number of citations of the paper that reports this interaction (PubMedID 11694537)
0

Data Source:
HPRD (in vitro)

		CR1	CD55
Description		complement C3b/C4b receptor 1 (Knops blood group)	CD55 molecule (Cromer blood group)
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GO Annotations	Cellular Component	Extracellular Space Cytoskeleton Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Golgi Membrane Extracellular Region Plasma Membrane Cell Surface Membrane Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Side Of Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Virus Receptor Activity Complement Binding Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Receptor Activity Complement Component C3b Receptor Activity Protein Binding	Virus Receptor Activity Protein Binding Lipid Binding
	Biological Process	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes T Cell Mediated Immunity Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement-dependent Cytotoxicity ATP Export	Immune System Process Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Symbiont Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade	Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs			Chloramphenicol
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Alzheimer's disease ( 21460840 31473137 19734903) Alzheimer's disease (late onset) ( 28714976 30617256 24162737 21460841) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)	Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4	8 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK SLC25A17 VPS26C
Entrez ID		1378	1604
HPRD ID		00398	00500
Ensembl ID		ENSG00000203710	ENSG00000196352
Uniprot IDs		E9PDY4 P17927	B1AP13 P08174
PDB IDs		1GKG 1GKN 1PPQ 2MCY 2MCZ 2Q7Z 5FO9	1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK 6LA5 7C9W 7DO4 7VY5 7VY6 8B8R 8K9R 8K9T
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Complement Activation Humoral Immune Response Symbiont Cell Surface Positive Regulation Of Immune System Process Immune Effector Process Regulation Of Complement Activation Activation Of Immune Response Defense Response Vertebrate Eye-specific Patterning Classical-complement-pathway C3/C5 Convertase Complex Cell Surface Innate Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Complement-mediated Synapse Pruning Regulation Of Immune System Process Defense Response To Symbiont Defense Response To Other Organism Immune System Process Complement Binding Positive Regulation Of Apoptotic Cell Clearance Regulation Of Immune Response Synapse Pruning Regulation Of Apoptotic Cell Clearance Response To Other Organism Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Neuron Remodeling Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Complement Activation, Alternative Pathway Opsonization Response To External Biotic Stimulus Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Stress Regulation Of Adaptive Immune Response Neuron Maturation Antigen Binding Endopeptidase Inhibitor Activity Positive Regulation Of Phagocytosis Virus Receptor Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Regulation Of Phagocytosis Inflammatory Response Leukocyte Activation Positive Regulation Of Activation Of Membrane Attack Complex	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response CD8 Receptor Binding Positive Regulation Of Immune Response CD4 Receptor Binding Secretory Granule Membrane Phospholipase Activator Activity T Cell Receptor Binding Complement Receptor Mediated Signaling Pathway Regulation Of Immune Response Phosphatidylinositol 3-kinase Binding ATP Transport Positive Regulation Of Immune System Process Immune System Process Phospholipase Binding Cell Surface Receptor Signaling Pathway Membrane Raft Adenine Nucleotide Transport Purine Nucleotide Transport Fc-gamma Receptor Signaling Pathway Nucleotide Transport Regulation Of Regulatory T Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Response To Xenobiotic Stimulus Regulation Of Immune System Process Fc Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Opsonin Receptor Activity Complement Component C3b Receptor Activity Positive Regulation Of Lymphocyte Activation Immune Complex Clearance By Erythrocytes Positive Regulation Of Cell-cell Adhesion Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Cellular Response To Glycine Response To Singlet Oxygen Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity FMN Transmembrane Transporter Activity FAD Transmembrane Transporter Activity FAD Transmembrane Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Carbohydrate Derivative Transport
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