CPB2 and TINAG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CPB2	TINAG
Description		carboxypeptidase B2	tubulointerstitial nephritis antigen
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Lysosome
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Proteolysis Blood Coagulation Hemostasis Fibrinolysis	Proteolysis Cell Adhesion
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade
Drugs		AZD-9684 Prothrombin
Diseases
GWAS		Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Morning person ( 30696823) QRS interval (sulfonylurea treatment interaction) ( 27958378) Radiation response ( 20923822)
Interacting Genes		7 interacting genes: A2M C5 DPYD F2 PLG PZP TINAG	3 interacting genes: CPB2 TERF1 TMEM45B
Entrez ID		1361	27283
HPRD ID		04374	09483
Ensembl ID		ENSG00000080618	ENSG00000137251
Uniprot IDs		A0A087WSY5 Q96IY4	Q6NSC1 Q9UJW2
PDB IDs		3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH 7NEE 7NEU
Enriched GO Terms of Interacting Partners?		Blood Microparticle Endopeptidase Inhibitor Activity Extracellular Space Signaling Receptor Binding Protease Binding Extracellular Matrix Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Extracellular Exosome Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Negative Regulation Of Complement Activation, Lectin Pathway Uracil Catabolic Process Coagulation Blood Coagulation Peptidase Inhibitor Activity Hemostasis Interleukin-8 Binding Receptor Ligand Activity Killing Of Cells Of Another Organism Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Purine Nucleobase Catabolic Process Serine-type Peptidase Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Wound Healing CMP Catabolic Process DUMP Catabolic Process Thrombospondin Receptor Activity Serine-type Endopeptidase Activity Trans-synaptic Signaling By BDNF	Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping DNA Binding, Bending Response To Pain Fibrinolysis Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Metallocarboxypeptidase Activity Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Carboxypeptidase Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Involved In Meiotic Cell Cycle Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of Telomere Maintenance Multicellular Organismal Response To Stress Negative Regulation Of Chromosome Organization Chromosome Localization
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