SDHAF4 and CYB5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDHAF4	CYB5B
Description		succinate dehydrogenase complex assembly factor 4	cytochrome b5 type B
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Protein Folding Chaperone	Protein Binding Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity
	Biological Process	Tricarboxylic Acid Cycle Protein Folding Mitochondrial Respiratory Chain Complex II Assembly Innate Immune Response Cellular Respiration	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress
Pathways		Maturation of TCA enzymes and regulation of TCA cycle	Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 29403010 30993211)
Interacting Genes		3 interacting genes: CD81 CYB5B UPK1B	58 interacting genes: AHNAK2 APP AQP6 B3GNT9 BIK BNIP3L BTNL9 CD33 CD79A CENPT CGRRF1 CLDN7 CLN8 COG8 CPLX4 CREB3 EBP ERGIC3 ESRP2 FAM209A FAM210B FKBP7 FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PHAF1 PLPP4 REEP4 RETREG3 RPS2P45 SDHAF4 SLC10A1 SLC10A6 SLC16A2 SLC35H1 SLC39A9 SLC60A2 SLC71A2 SLC7A6OS STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B
Entrez ID		135154	80777
HPRD ID		12888	13106
Ensembl ID		ENSG00000154079	ENSG00000103018
Uniprot IDs		Q5VUM1	O43169
PDB IDs		8DYD 8DYE	3NER
Enriched GO Terms of Interacting Partners?		Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Myoblast Fusion Involved In Skeletal Muscle Regeneration Apical Plasma Membrane Urothelial Plaque Nitric-oxide Synthase Complex MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Nitrite Reductase (NO-forming) Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Tetraspanin-enriched Microdomain Positive Regulation Of Protein Exit From Endoplasmic Reticulum Transferrin Receptor Binding Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Immunological Synapse Formation Regulation Of Receptor Clustering Positive Regulation Of Type 2 Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Protein Exit From Endoplasmic Reticulum Nitric Oxide Biosynthetic Process Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation MHC Class II Protein Complex Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Myoblast Fusion Positive Regulation Of T Cell Cytokine Production Cellular Response To Low-density Lipoprotein Particle Stimulus Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Type 2 Immune Response Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Immunoglobulin Mediated Immune Response Regulation Of T Cell Cytokine Production T Cell Costimulation B Cell Mediated Immunity Immunological Synapse Positive Regulation Of B Cell Proliferation Regulation Of Macrophage Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cholesterol Binding	Membrane
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