STXBP5 and STX4

Number of citations of the paper that reports this interaction (PubMedID 12832401)
0

Data Source:
HPRD (in vitro)

		STXBP5	STX4
Description		syntaxin binding protein 5	syntaxin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Acetylcholine-gated Channel Complex Synaptic Vesicle Membrane Cytoplasmic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Synapse Extrinsic Component Of Neuronal Dense Core Vesicle Membrane Hippocampal Mossy Fiber To CA3 Synapse Presynapse	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Syntaxin-1 Binding Syntaxin Binding Myosin II Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Regulation Of Synaptic Vesicle Priming Protein Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways			Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bronchopulmonary dysplasia ( 23897914) Factor VIII levels ( 30586737) Heel bone mineral density x serum urate levels interaction ( 34046847) Low vWF levels ( 26486471) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma plasminogen activator levels ( 24578379) Systolic blood pressure ( 30224653) Venous thromboembolism ( 31420334) vWF levels ( 20231535 30586737) White blood cell count ( 32888494)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: SNAP23 STX1A STX4	65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1
Entrez ID		134957	6810
HPRD ID		06845	01722
Ensembl ID		ENSG00000164506	ENSG00000103496
Uniprot IDs		A0A9L9PXY2 H0Y332 Q5T5C0	B7Z425 Q12846
PDB IDs
Enriched GO Terms of Interacting Partners?		SNARE Complex SNAP Receptor Activity Organelle Membrane Fusion Vesicle Fusion Organelle Fusion Membrane Fusion SNARE Complex Assembly Exocytosis Specific Granule Vesicle Organization Neuron Projection Secretion By Cell Positive Regulation Of Regulated Secretory Pathway Secretion Regulation Of Hormone Levels Vesicle Docking SNARE Binding Membrane Organization Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Positive Regulation Of Exocytosis Membrane Docking Hormone Secretion Schaffer Collateral - CA1 Synapse Neurotransmitter Transport Hormone Transport Synapse Regulation Of Regulated Secretory Pathway Myosin Head/neck Binding Sphingomyelin Phosphodiesterase Activator Activity Positive Regulation Of Synaptic Transmission Protein Transport Signal Release Regulation Of Insulin Secretion Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Storage Vacuole Regulation Of Exocytosis Regulation Of Peptide Hormone Secretion Establishment Of Protein Localization Protein-containing Complex Assembly Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Neuron Projection Membrane Protein-containing Complex Organization Regulation Of Hormone Secretion Regulation Of Protein Secretion Endomembrane System Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex	SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport
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