CORT and SSTR5

Number of citations of the paper that reports this interaction (PubMedID 9125122)
0

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		CORT	SSTR5
Description		cortistatin	somatostatin receptor 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Synapse	Plasma Membrane Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Cell Migration	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Vapreotide Pasireotide Lanreotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68
Diseases
GWAS		Male-pattern baldness ( 28196072)	Logical memory (immediate recall) in normal cognition ( 29274321) Polycystic ovary syndrome ( 25574032)
Interacting Genes		7 interacting genes: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	10 interacting genes: ADCY10 CNR1 CORT DRD2 GOPC KAT8 PDZK1 PEX5 SST SSTR1
Entrez ID		1325	6755
HPRD ID		04150	01677
Ensembl ID		ENSG00000241563	ENSG00000162009
Uniprot IDs		O00230 Q8IUV6	P35346
PDB IDs		7S8L 7S8M 7VDL 7VV4 8X8L	8X8L 8X8N 8ZBE 8ZCJ
Enriched GO Terms of Interacting Partners?		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuron Projection Response To Glucocorticoid Response To Corticosteroid Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation Response To Lipid Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Response To Hormone Signal Transduction Plasma Membrane Cellular Response To Estradiol Stimulus Positive Regulation Of Cytokinesis Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Mast Cell Secretagogue Receptor Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Membrane Regulation Of Insulin Secretion Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Hormone-mediated Apoptotic Signaling Pathway Regulation Of Cell Division Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process	G Protein-coupled Receptor Signaling Pathway Somatostatin Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling GABA-ergic Synapse Regulation Of Monoatomic Anion Transport Positive Regulation Of Developmental Growth Positive Regulation Of Multicellular Organism Growth Signaling Cell-cell Signaling Telencephalon Cell Migration Positive Regulation Of Growth Forebrain Cell Migration Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Bicarbonate Binding Negative Regulation Of Anion Channel Activity Cannabinoid Receptor Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Forebrain Development Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Retraction Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Protein Propionyltransferase Activity Axon Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Synapse Regulation Of Monoatomic Ion Transport Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Regulation Of Protein Localization Negative Regulation Of Dopamine Receptor Signaling Pathway Peroxisome Targeting Sequence Binding Central Region Of Growth Cone Hormone Activity Neuromuscular Process Response To Estradiol Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dendrite
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