CPNE4 and CCDC22

Number of citations of the paper that reports this interaction (PubMedID 12522145)
0

Data Source:
HPRD (two hybrid, in vitro)

		CPNE4	CCDC22
Description		copine 4	CCC complex scaffolding subunit CCDC22
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synapse Extracellular Exosome Glutamatergic Synapse	Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cytoskeleton
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Protein Binding Cullin Family Protein Binding
	Biological Process	Cellular Response To Calcium Ion	Intracellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Protein Transport Endocytic Recycling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis ( 22959728) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Body mass index ( 25673413 28892062 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Circulating leptin levels in high cardiovascular risk ( 31766143) Coronary artery aneurysm in Kawasaki disease ( 27171184) Eosinophilic esophagitis ( 34506852) HDL cholesterol levels ( 32203549) Intracranial aneurysm ( 29531279) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Metabolic syndrome ( 31589552) Motion sickness ( 25628336) Neutrophil count ( 21507922) Retinitis pigmentosa ( 33514863)	Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: ACAD11 ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP NECAB1 PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O	8 interacting genes: ACTG1 ARSA BLOC1S6 CPNE1 CPNE4 KRT27 OIP5 USHBP1
Entrez ID		131034	28952
HPRD ID		05017	06594
Ensembl ID		ENSG00000196353	ENSG00000101997
Uniprot IDs		B7Z370 Q4G168 Q96A23	O60826
PDB IDs			8F2U 8P0V 8P0W 8P0X
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Cortical Cytoskeleton Nucleoplasm Cytoplasm Apical Protein Localization Structural Constituent Of Cytoskeleton Cytoskeleton Cytosol Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein-containing Complex Binding Regulation Of Intracellular Signal Transduction Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Receptor Localization To Synapse Regulation Of Early Endosome To Late Endosome Transport Actin Filament Capping Blastocyst Hatching Regulation Of Protein Localization To Membrane Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Cell Communication Vesicle-mediated Transport Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Tooth Mineralization BCOR Complex Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Establishment Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Heat Shock Protein Binding Golgi Inheritance Central Nervous System Formation Golgi To Plasma Membrane Transport NEDD8 Conjugating Enzyme Activity Regulation Of Vesicle-mediated Transport Ubiquitin-protein Transferase Activity Glutamatergic Synapse Nucleus Transporter Regulator Activity	Filamentous Actin Basal Body Patch Cerebroside-sulfatase Activity Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle
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