COL17A1 and KRT18

Number of citations of the paper that reports this interaction (PubMedID 10022517)
0

Data Source:
HPRD (two hybrid, in vitro)

		COL17A1	KRT18
Description		collagen type XVII alpha 1 chain	keratin 18
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Membrane Hemidesmosome Extracellular Matrix Anchoring Junction	Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Adherens Junction Nuclear Matrix Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cell-matrix Adhesion Epidermis Development Hemidesmosome Assembly	Anatomical Structure Morphogenesis Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Cardiac hypertrophy ( 21348951)	Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN	94 interacting genes: AIRIM BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 FXR1 FXR2 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4B PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		1308	3875
HPRD ID		00223	01020
Ensembl ID		ENSG00000065618	ENSG00000111057
Uniprot IDs		Q9UMD9	P05783
PDB IDs		8IZS
Enriched GO Terms of Interacting Partners?		Cell-substrate Junction Organization Cell-substrate Junction Assembly Anchoring Junction Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Hemidesmosome Cell Junction Organization Cell-cell Adhesion Intermediate Filament Structural Molecule Activity Wound Healing Cell Adhesion Response To Wounding Focal Adhesion Cell Junction Assembly Extracellular Exosome Z Disc Neuregulin Binding Integrin Binding Cadherin Binding Nail Development Fascia Adherens Cytoskeleton Organization Skin Morphogenesis Insulin-like Growth Factor I Binding Stress Fiber Basement Membrane Muscle Cell Development Pseudopodium Cell Periphery Integrin-mediated Signaling Pathway Structural Constituent Of Cytoskeleton Myelination In Peripheral Nervous System Actin Cytoskeleton Integrin Complex Plasma Membrane Cytoskeleton Anatomical Structure Morphogenesis Desmosome Actin Binding Cell-cell Junction Organization Cell Morphogenesis Adherens Junction Negative Regulation Of Blood Vessel Branching Integrin Alpha6-beta4 Complex X11-like Protein Binding Actin Filament Binding Cell Junction Cell-cell Junction	Cytosol Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Cytoplasm Organelle Organization Cytoskeleton Organization Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Cytoskeleton Establishment Of Protein Localization Nucleus Developmental Process Supramolecular Fiber Organization BBSome Regulation Of Apoptotic Process Intracellular Protein Localization Protein Domain Specific Binding Regulation Of Programmed Cell Death Cellular Component Assembly Centrosome Regulation Of Protein Metabolic Process Keratinization Establishment Of Localization In Cell Reproductive Process Response To Lipid Enzyme Binding Apoptotic Process Protein Binding Regulation Of Cellular Component Organization Programmed Cell Death Cell Death Cellular Response To Staurosporine Ciliary Basal Body Cellular Localization Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Protein Localization Intracellular Signal Transduction Hippocampus Development Regulation Of Microtubule Nucleation Phosphoserine Residue Binding Focal Adhesion Pyroptotic Inflammatory Response Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Death-inducing Signaling Complex Desmosome Assembly
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